Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.

Autor: Gillette MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, 02115, USA. Electronic address: gillette@broadinstitute.org., Satpathy S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA. Electronic address: shankha@broadinstitue.org., Cao S; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Dhanasekaran SM; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Vasaikar SV; Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, 77030, USA., Krug K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Petralia F; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Li Y; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Liang WW; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Reva B; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Krek A; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ji J; Department of Population Health Science and Policy; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Song X; Department of Population Health Science and Policy; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Liu W; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Hong R; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Yao L; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Blumenberg L; Institute for Systems Genetics and Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Savage SR; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 77030, USA., Wendl MC; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Wen B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 77030, USA., Li K; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 77030, USA., Tang LC; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA; Department of Biological Sciences, Columbia University, New York, NY, 10027, USA., MacMullan MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA; Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, 90089, USA., Avanessian SC; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Kane MH; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Newton CJ; Van Andel Research Institute, Grand Rapids, MI, 49503, USA., Cornwell M; Institute for Systems Genetics and Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Kothadia RB; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Ma W; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Yoo S; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mannan R; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Vats P; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Kumar-Sinha C; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Kawaler EA; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Omelchenko T; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Colaprico A; Department of Public Health Sciences, University of Miami, Miller School of Medicine, Miami, FL, 33136, USA., Geffen Y; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Maruvka YE; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., da Veiga Leprevost F; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Wiznerowicz M; Poznan University of Medical Sciences, Poznań, 61-701, Poland; International Institute for Molecular Oncology, Poznań, 60-203, Poland., Gümüş ZH; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Veluswamy RR; Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hostetter G; Van Andel Research Institute, Grand Rapids, MI, 49503, USA., Heiman DI; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Wyczalkowski MA; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Hiltke T; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Mesri M; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Kinsinger CR; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Boja ES; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Omenn GS; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Chinnaiyan AM; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Rodriguez H; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Li QK; Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD, 21224, USA., Jewell SD; Van Andel Research Institute, Grand Rapids, MI, 49503, USA., Thiagarajan M; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA., Getz G; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Zhang B; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 77030, USA., Fenyö D; Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY 10016, USA., Ruggles KV; Institute for Systems Genetics and Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA., Cieslik MP; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Robles AI; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD, 20892, USA., Clauser KR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Govindan R; Division of Oncology and Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA., Wang P; Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nesvizhskii AI; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Ding L; Department of Medicine and Genetics, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA., Mani DR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA., Carr SA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA. Electronic address: scarr@broad.mit.edu.

Publikováno v: Cell [Cell] 2020 Jul 09; Vol. 182 (1), pp. 200-225.e35.