Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration

Autor: Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A. Fornal, Billy C. Wang, Ryan C. Martin, Elsa A. Olson, Ammar L. Ujjainwala, David M. Pinson, Jeffrey D. Klopfenstein, Krishna Kumar Veeravalli

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

We recently showed that the post-ischemic induction of matrix metalloproteinase-12 (MMP-12) in the brain degrades tight junction proteins, increases MMP-9 and TNFα expression, and contributes to the blood-brain barrier (BBB) disruption, apoptosis, d

Externí odkaz: https://doaj.org/article/c74371e382664aa2abd604cbe388854c

Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Autor: Bharath Chelluboina, Koteswara Rao Nalamolu, Gustavo G. Mendez, Jeffrey D. Klopfenstein, David M Pinson, David Z Wang, Krishna Kumar Veeravalli

Publikováno v: Cellular Physiology and Biochemistry, Vol 44, Iss 4, Pp 1360-1369 (2017)

Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) in a rat model of ischemic strok

Externí odkaz: https://doaj.org/article/80c34aa392184e2d9c752d08a80d3852

The interplay between MMP-12 and t-PA in the brain after ischemic stroke

Autor: Siva Reddy Challa, Koteswara Rao Nalamolu, Casimir A. Fornal, Adithya Mohandass, Justin P. Mussman, Claire Schaibley, Aanan Kashyap, Vinay Sama, Billy C. Wang, Jeffrey D. Klopfenstein, David M. Pinson, Adinarayana Kunamneni, Krishna Kumar Veeravalli

Publikováno v: Neurochemistry international. 161

Tissue-type plasminogen activator (t-PA) expression is known to increase following transient focal cerebral ischemia and reperfusion. Previously, we reported downregulation of t-PA upon suppression of matrix metalloproteinase-12 (MMP-12), following t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057895e067d366c23b943fb09d9095e0
https://pubmed.ncbi.nlm.nih.gov/36283468

Exosomes Treatment Mitigates Ischemic Brain Damage but Does Not Improve Post-Stroke Neurological Outcome

Autor: David Z. Wang, Adithya Mohandass, Koteswara Rao Nalamolu, David M. Pinson, Krishna Kumar Veeravalli, Jeffrey D. Klopfenstein, Ishwarya Venkatesh

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Cellular Physiology and Biochemistry, Vol 52, Iss 6, Pp 1280-1291 (2019)

Background/aims Recent studies demonstrated that the treatment with mesenchymal stem cells (MSCs) obtained from the human umbilical cord blood improved survival, reduced brain damage, prevented apoptosis, suppressed inflammatory responses, downregula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f074b16eec08d48c2d1ece6b11cc2ce
http://europepmc.org/articles/PMC6996798

Abstract TP100: Post-Transcriptional Inactivation of MMP-12 Immediately After Reperfusion Facilitates Neurological Recovery After Ischemic Stroke

Autor: Jeffrey D. Klopfenstein, David M. Pinson, Siva Reddy Challa, Ryan C. Martin, Krishna Kumar Veeravalli, Ramaswamy Kalyanasundaram, Amma L Ujjainwala, Elsa Olson, Koteswara Rao Nalamolu, Raghu Vemuganti

Publikováno v: Stroke. 51

Introduction: We recently showed in a rodent model of transient focal cerebral ischemia that matrix metalloproteinase-12 (MMP-12) induction in the ischemic brain promotes post-stroke blood-brain barrier disruption, apoptosis, demyelination, and infar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b67ffd3cab0c881463728740b1d4a4d
https://doi.org/10.1161/str.51.suppl_1.tp100