Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kotaro Yokote"'
Autor:
Atsushi Tanaka, Isao Taguchi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Hirofumi Tomiyama, Masataka Sata, Akira Sezai, Kazuo Eguchi, Toru Kato, Shigeru Toyoda, Ryoichi Ishibashi, Kazuomi Kario, Tomoko Ishizu, Shinichiro Ueda, Koji Maemura, Yukihito Higashi, Hirotsugu Yamada, Mitsuru Ohishi, Kotaro Yokote, Toyoaki Murohara, Jun-Ichi Oyama, Koichi Node, PRIZE study investigators
Publikováno v:
PLoS Medicine, Vol 17, Iss 4, p e1003095 (2020)
BackgroundAn elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, al
Externí odkaz:
https://doaj.org/article/f72a09fd60fc40b889b59a7f8f3ef9f8
Autor:
Yasushi Mandai, Daisuke Takahashi, Koji Hase, Yuuki Obata, Yukihiro Furusawa, Masashi Ebisawa, Tomoo Nakagawa, Toru Sato, Tatsuro Katsuno, Yasushi Saito, Takeshi Shimaoka, Osamu Yokosuka, Kotaro Yokote, Hiroshi Ohno
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65488 (2013)
CD4(+) T cells play a central role in the development of inflammatory bowel disease (IBD) via high-level production of effector cytokines such as IFN-γ and TNF-α. To better characterize the colitogenic CD4(+) T cells, we examined their expression o
Externí odkaz:
https://doaj.org/article/905ce0f838e14a4c85202cbd37e0c2a5
Autor:
Akiko Ishida, Kotaro Yokote, Tomoaki Tanaka, Ichiro Tatsuno, Akitoshi Nakayama, Hisashi Koide
Publikováno v:
Journal of the Endocrine Society
[Introduction] AKAP13 (Protein Kinase A Anchoring Protein 13) is a guanine nucleotides exchange factor (GEF) that activates RhoA as well as a scaffold protein integrating multiple signaling cascades. Previous study has shown that Akap13 hetero knocko
Autor:
Takashi Higashide, Tomoaki Tanaka, Ken Motoori, Yukio Nakatani, Toshiki Kazama, Tomohiko Ichikawa, Masae Uehara, Hidekazu Nagano, Nobusada Funabashi, Kotaro Yokote, Yoshio Kobayashi, Kohei Inoue, Hiroyuki Takaoka, Takashi Uno
Publikováno v:
International Journal of Cardiology. 168:3254-3258
Adrenal vein (AV) sampling (AVS) is the diagnostic gold standard for primary aldosteronism (PA), but right-sided AVS is difficult. We compared detection of AVs by selective retrograde CT adrenal venography (SRCTAV) with digital subtraction angiograph
Autor:
Atsushi Iwama, Chiaki Nakaseko, Tomoya Muto, Motohiko Oshima, Kazuya Shimoda, Changshan Wang, Kotaro Yokote, Shuhei Koide, Atsunori Saraya, Nagisa Hasegawa, Kiyoko Takane, Atsushi Kaneda, Goro Sashida, Hirotaka Matsui
Publikováno v:
Leukemia. 31(4)
Somatic inactivating mutations in epigenetic regulators are frequently found in combination in myelodysplastic syndrome (MDS). However, the mechanisms by which combinatory mutations in epigenetic regulators promote the development of MDS remain unkno
Autor:
Osamu Yokosuka, Yasushi Saito, Yoshiko Noguchi, Tomoo Nakagawa, Kotaro Yokote, Toru Sato, Atsuko Tokumasa, Tatsuro Katsuno, Kiyoshi Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 405:521-526
Deficiency of Smad3, an intracellular mediator of TGF-β, was shown to significantly accelerate re-epithelialization of the colonic mucosa. This study was performed to investigate the molecular mechanisms by which Smad3 controls colonic epithelial ce
Autor:
Ichiro Tatsuno, Naoko Hashimoto, Takahumi Mayama, Tomoaki Tanaka, Keiko Suyama, Kotaro Yokote, Emi Imada, Tomohiko Yoshida, Ikki Sakuma, Hidekazu Nagano
Publikováno v:
The Japanese Journal of Sarcoidosis and Other Granulomatous Disorders. 30:59-65
Autor:
Norihiko Watanabe, Daisuke Kashiwakuma, Hiroshi Nakajima, Akira Suto, Shin-ichiro Kagami, Michael J. Grusby, Itsuo Iwamoto, Yasushi Saito, Toshinori Nakayama, Kotaro Yokote, Koichi Hirose
Publikováno v:
The Journal of Experimental Medicine
It has recently been shown that interleukin (IL)-21 is produced by Th17 cells, functions as an autocrine growth factor for Th17 cells, and plays critical roles in autoimmune diseases. In this study, we investigated the differentiation and characteris
Autor:
Hiroyuki Daida, Tamio Teramoto, Jun Sasaki, Genshi Egusa, Sadatoshi Biro, Kazuaki Shimamoto, Tohru Funahashi, Kazuhiko Hirobe, Kotaro Yokote, Masayuki Yokode, Makoto Kinoshita, Hirotsugu Ueshima
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 14:155-158
Epidemiological studies have shown that the incidence of coronary artery disease increases as the LDL- C, TC1-9), and TG10, 11) levels rise and the HDL-C level lowers5, 8, 12) both in Japan and in Western countries (Fig.1). At present, prevalence of
Autor:
Atsushi Iwama, Yuichi Shiraishi, Yukio Kobayashi, Kenichi Chiba, Yasuhiko Miyazaki, Hirokazu Okumura, June Takeda, Yusuke Shiozawa, Norio Asou, Itaru Matsumura, Naoto Takahashi, Yoshihisa Morishita, Emiko Sakaida, Hitoshi Kiyoi, Hirokazu Tanaka, Kiyotoshi Imai, Motohiko Oshima, Chiaki Nakaseko, Shin Fujisawa, Akihiro Takeshita, Atsunori Saraya, Kenichi Yoshida, Noriko Usui, Kotaro Yokote, Satoru Miyano, Emi Togasaki, Kazunori Ohnishi, Tomoki Naoe, Chikara Hirase, Masahiro Takeuchi, Shigeki Ohtake, Seishi Ogawa
Publikováno v:
Blood Cancer Journal
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must continue TKI therapy for indefinite periods. In this stud