Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kotaro Tsuboyama"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0270097 (2022)
Although recombinant proteins are widely used in biotechnology and pharmaceutical industries, improving their solubility and stability is often a challenging issue. We recently discovered a class of highly unstructured heat-resistant obscure (Hero) p
Externí odkaz:
https://doaj.org/article/afd1cdc55cae4f66907f0f126fe73c47
Autor:
Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, Masaaki Oyama, Yoshiho Ikeuchi, Shintaro Iwasaki, Yukihide Tomari
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000632 (2020)
Proteins are typically denatured and aggregated by heating at near-boiling temperature. Exceptions to this principle include highly disordered and heat-resistant proteins found in extremophiles, which help these organisms tolerate extreme conditions
Externí odkaz:
https://doaj.org/article/28e67304b91b48d8a4a24dd40b3c60e0
Autor:
Kotaro Tsuboyama, Justas Dauparas, Jonathan Chen, Elodie Laine, Yasser Mohseni Behbahani, Jonathan J. Weinstein, Niall M. Mangan, Sergey Ovchinnikov, Gabriel J. Rocklin
Datasets and scriptsfor BioRixv manuscript titled "Mega-scale experimental analysis of protein folding stability in biology and protein design" URL:https://doi.org/10.1101/2022.12.06.519132 *** IMPORTANT! Pleaseregister your useof these data so that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c29576efc048a875a7591248b13d35
Misfolding and aggregation of proteins are characteristic features in the progression of neurodegenerative diseases. While molecular chaperones are well-known suppressors of these aberrant events, we recently reported that a widespread family of heat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4f06251055d350bcbd729f321573c3
https://doi.org/10.1101/2022.11.15.516569
https://doi.org/10.1101/2022.11.15.516569
Autor:
Tae-Eun Kim, Kotaro Tsuboyama, Scott Houliston, Cydney M. Martell, Claire M. Phoumyvong, Alexander Lemak, Hugh K. Haddox, Cheryl H. Arrowsmith, Gabriel J. Rocklin
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Designing entirely new protein structures remains challenging because we do not fully understand the biophysical determinants of folding stability. Yet some protein folds are easier to design than others. Previous work identified the 43-residue □β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc860100db8124e1a0fce01dfd70a01
https://doi.org/10.1073/pnas.2122676119
https://doi.org/10.1073/pnas.2122676119
Autor:
Gabriel J. Rocklin, Kotaro Tsuboyama
Publikováno v:
Biophysical Journal. 122:17a-18a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc597d8a7113b6fc9f95bf84415fd23
https://doi.org/10.1016/j.bpj.2022.11.321
https://doi.org/10.1016/j.bpj.2022.11.321
Autor:
Shintaro Iwasaki, Masaaki Oyama, Yuki Okada, Yukihide Tomari, Kotaro Tsuboyama, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yoshiho Ikeuchi, Tatsuya Osaki
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000632 (2020)
PLoS Biology
PLoS Biology
Proteins are typically denatured and aggregated by heating at near-boiling temperature. Exceptions to this principle include highly disordered and heat-resistant proteins found in extremophiles, which help these organisms tolerate extreme conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba9d62a630561b4d802489867d54ab
https://doi.org/10.1101/816124
https://doi.org/10.1101/816124
Autor:
Kotaro Tsuboyama1, Ikuko Koyama-Honda1, Yuriko Sakamaki2, Masato Koike3, Hideaki Morishita1, Noboru Mizushima1 nmizu@m.u-tokyo.ac.jp
Publikováno v:
Science. 11/25/2016, Vol. 354 Issue 6315, p1036-1041. 6p. 4 Graphs.
Autor:
Haruhisa Okawa, Sidney P. Kuo, Mrinalini Hoon, Fred Rieke, Sachihiro C. Suzuki, Takeshi Yoshimatsu, Luca Della Santina, Rachel O.L. Wong, Kotaro Tsuboyama
Publikováno v:
Current Biology. 26:2070-2077
Excitatory and inhibitory neurons in the CNS are distinguished by several features, including morphology, transmitter content, and synapse architecture [1]. Such distinctions are exemplified in the vertebrate retina. Retinal bipolar cells are polariz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab190aa75b8b8474032117036409944
https://doi.org/10.1016/j.cub.2016.06.016
https://doi.org/10.1016/j.cub.2016.06.016