Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Kotaro Shirakawa"'
Autor:
Hiroki Futatsusako, Rina Hashimoto, Masaki Yamamoto, Jumpei Ito, Yasufumi Matsumura, Hajime Yoshifuji, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kei Sato, Miki Nagao, Kazuo Takayama
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109597- (2024)
Summary: A primary reason for the ongoing spread of coronavirus disease 2019 (COVID-19) is the continuous acquisition of mutations by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism of acquiring mutations is n
Externí odkaz:
https://doaj.org/article/008d9180ada1461eb8bfedb9a9288e05
Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection
Autor:
Tomokazu Tamura, Hayato Ito, Shiho Torii, Lei Wang, Rigel Suzuki, Shuhei Tsujino, Akifumi Kamiyama, Yoshitaka Oda, Masumi Tsuda, Yuhei Morioka, Saori Suzuki, Kotaro Shirakawa, Kei Sato, Kumiko Yoshimatsu, Yoshiharu Matsuura, Satoshi Iwano, Shinya Tanaka, Takasuke Fukuhara
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109647- (2024)
Summary: Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary choice for accommodation within viral genome. However, NanoL
Externí odkaz:
https://doaj.org/article/72d667b5cec7492a9e0e4f4a792226c2
Autor:
MST Monira Begum, Kimiko Ichihara, Otowa Takahashi, Hesham Nasser, Michael Jonathan, Kenzo Tokunaga, Isao Yoshida, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kei Sato, Terumasa Ikeda, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Zannatul Ferdous, Kenji Shishido, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Saori Suzuki, Hayato Ito, Jumpei Ito, Yu Kaku, Naoko Misawa, Arnon Plianchaisuk, Ziyi Guo, Alfredo Jr. Hinay, Keiya Uriu, Yusuke Kosugi, Shigeru Fujita, Jarel Elgin Mendoza Tolentino, Luo Chen, Lin Pan, Mai Suganami, Mika Chiba, Ryo Yoshimura, Kyoko Yasuda, Keiko Iida, Naomi Ohsumi, Adam Patrick Strange, Hiroyuki Asakura, So Nakagawa, Akifumi Takaori-Kondo, Kotaro Shirakawa, Kayoko Nagata, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Yukio Watanabe, Ayaka Sakamoto, Naoko Yasuhara, Takao Hashiguchi, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Hisano Yajima, Takashi Irie, Ryoko Kawabata, Kaori Tabata, Ryo Shimizu, Yuka Mugita, Takamasa Ueno, Chihiro Motozono, Mako Toyoda, Akatsuki Saito, Maya Shofa, Yuki Shibatani, Tomoko Nishiuchi
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
IntroductionThe severe acute respiratory syndrome coronavirus (SARS-CoV-2) spike (S) protein is essential in mediating membrane fusion of the virus with the target cells. Several reports demonstrated that SARS-CoV-2 S protein fusogenicity is reported
Externí odkaz:
https://doaj.org/article/5d2678f123154258a7ff9b66e6f6851e
Autor:
Yuuka Masuda, Hesham Nasser, Jiri Zahradnik, Shuya Mitoma, Ryo Shimizu, Kayoko Nagata, Akifumi Takaori-Kondo, Gideon Schreiber, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Kotaro Shirakawa, Akatsuki Saito, Terumasa Ikeda, Jumpei Ito, Kei Sato
Publikováno v:
Frontiers in Virology, Vol 3 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has substantially diversified during the pandemic, resulting in the successive emergence of variants characterized by various mutations. It has been observed that several epidemic variants,
Externí odkaz:
https://doaj.org/article/ba57fdf08fff498fb71144b8613e9fd2
Autor:
Kayoko Nagata, Daichi Utsumi, Masamitsu N. Asaka, Ryota Maeda, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yohei Yanagida, Yugo Kawai, Kei Sato, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Yasuhiro Yasutomi, Akihiro Imura, Akifumi Takaori-Kondo
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-6 (2022)
Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail al
Externí odkaz:
https://doaj.org/article/10418e3e410846ef990c3a56f313ff36
Autor:
Ryota Maeda, Junso Fujita, Yoshinobu Konishi, Yasuhiro Kazuma, Hiroyuki Yamazaki, Itsuki Anzai, Tokiko Watanabe, Keishi Yamaguchi, Kazuki Kasai, Kayoko Nagata, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Kotaro Shirakawa, Kei Sato, Fumiaki Makino, Yoshiharu Matsuura, Tsuyoshi Inoue, Akihiro Imura, Keiichi Namba, Akifumi Takaori-Kondo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
A panel of nanobodies are presented that can detect the spike proteins of five SARS-CoV-2 variants of concern and structural analyses show that one clone targets conserved epitopes on the receptor-binding domain and contacts the N-terminal domain.
Externí odkaz:
https://doaj.org/article/ebff1ac040bc4897b219b41bbbf0ca49
Autor:
Yasuhiro Kazuma, Kotaro Shirakawa, Yusuke Tashiro, Hiroyuki Yamazaki, Ryosuke Nomura, Yoshihito Horisawa, Suguru Takeuchi, Emani Stanford, Yoshinobu Konishi, Hiroyuki Matsui, Tadahiko Matsumoto, Fumiko Tanabe, Ryo Morishita, Shinji Ito, Akifumi Takaori-Kondo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuclei, however, the regulatory mec
Externí odkaz:
https://doaj.org/article/7d400becc0de46478b6b4de3e4025404
Autor:
Izumi Kimura, Daichi Yamasoba, Hesham Nasser, Jiri Zahradnik, Yusuke Kosugi, Jiaqi Wu, Kayoko Nagata, Keiya Uriu, Yuri L. Tanaka, Jumpei Ito, Ryo Shimizu, Toong Seng Tan, Erika P. Butlertanaka, Hiroyuki Asakura, Kenji Sadamasu, Kazuhisa Yoshimura, Takamasa Ueno, Akifumi Takaori-Kondo, Gideon Schreiber, Mako Toyoda, Kotaro Shirakawa, Takashi Irie, Akatsuki Saito, So Nakagawa, Terumasa Ikeda, Kei Sato
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105720- (2022)
Summary: Recent studies have revealed the unique virological characteristics of Omicron, particularly those of its spike protein, such as less cleavage efficacy in cells, reduced ACE2 binding affinity, and poor fusogenicity. However, it remains uncle
Externí odkaz:
https://doaj.org/article/68c61f21418441b58860e4f5398388dc
Autor:
Hesham Nasser, Ryo Shimizu, Jumpei Ito, Akatsuki Saito, Kei Sato, Terumasa Ikeda, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Mai Kishimoto, Shinya Tanaka, Masumi Tsuda, Lei Wang, Yoshikata Oda, Marie Kato, Zannatul Ferdous, Hiromi Mouri, Kenji Shishido, Takasuke Fukuhara, Tomokazu Tamura, Rigel Suzuki, Hayato Ito, Daichi Yamasoba, Izumi Kimura, Naoko Misawa, Keiya Uriu, Yusuke Kosugi, Shigeru Fujita, Mai Suganami, Mika Chiba, Ryo Yoshimura, So Nakagawa, Jiaqi Wu, Akifumi Takaori-Kondo, Kotaro Shirakawa, Kayoko Nagata, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yusuke Tashiro, Yugo Kawai, Takashi Irie, Ryoko Kawabata, MST Monira Begum, Otowa Takahashi, Kimiko Ichihara, Takamasa Ueno, Chihiro Motozono, Mako Toyoda, Yuri L. Tanaka, Erika P. Butlertanaka, Maya Shofa, Kazuo Takayama, Rina Hashimoto, Sayaka Deguchi, Takao Hashiguchi, Tateki Suzuki, Kanako Kimura, Jiei Sasaki, Yukari Nakajima, Kaori Tabata
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101773- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mediates membrane fusion between the virus and the target cells, triggering viral entry into the latter. Here, we describe a SARS-CoV-2 spike-protein-mediated membran
Externí odkaz:
https://doaj.org/article/29370f9faa774a2b998e2833a7d82fe9
Autor:
Anamaria D. Sarca, Luca Sardo, Hirofumi Fukuda, Hiroyuki Matsui, Kotaro Shirakawa, Kazuki Horikawa, Akifumi Takaori-Kondo, Taisuke Izumi
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
HIV-1 infectivity is achieved through virion maturation. Virus particles undergo structural changes via cleavage of the Gag polyprotein mediated by the viral protease, causing the transition from an uninfectious to an infectious status. The majority
Externí odkaz:
https://doaj.org/article/385ded9ba1f14fd0ad1999b8cb4ba1a1