Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kotaro Koyama"'
Autor:
Tsuyoshi Nakano, Takashi Sugimura, Osamu Yata, Yasuko Matsumoto, Keiji Wakabayashi, Masafumi Yamamoto, Ken-Ichi Odagiri, Kotaro Koyama, Yuko Matsushima-Hibiya
Publikováno v:
Proceedings of the National Academy of Sciences. 105:2516-2520
Cabbage butterflies, Pieris rapae and Pieris brassicae , contain strong cytotoxic proteins, designated as pierisin-1 and -2, against cancer cell lines. These proteins exhibit DNA ADP-ribosylating activity. To determine the distribution of substances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82be28be08088720780d3426d2cbf2e7
https://doi.org/10.1073/pnas.0712221105
https://doi.org/10.1073/pnas.0712221105
Publikováno v:
Biochemical and Biophysical Research Communications. 323:579-582
Pierisin-2 is a cytotoxic and apoptosis-inducing protein present in Pieris brassicae with a 91% homology in the deduced amino acid sequences to pierisin-1 from Pieris rapae. We earlier showed pierisin-1 to catalyze mono(ADP-ribosyl)ation of 2'-deoxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f666323503a913869c19e55ed469a131
https://doi.org/10.1016/j.bbrc.2004.08.132
https://doi.org/10.1016/j.bbrc.2004.08.132
Autor:
Takeshi Kasama, Masahiko Watanabe, Takashi Sugimura, Kazuya I.P.J. Hidari, Daisei Miyamoto, Keiji Wakabayashi, Takashi Kanazawa, Yasuo Suzuki, Kotaro Koyama, Yuko Matsushima-Hibiya
Publikováno v:
Journal of Biological Chemistry. 278:9972-9978
Pierisin-1, a cytotoxic protein found naturally in the cabbage butterfly, induces apoptosis of mammalian cells. Our recent studies suggest that pierisin-1 consists of an N-terminal ADP-ribosyltransferase domain, and a C-terminal region that binds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09da46af29cd5d4879928d240849439
https://doi.org/10.1074/jbc.m212114200
https://doi.org/10.1074/jbc.m212114200
Autor:
Takashi Sugimura, Takashi Kanazawa, Noriaki Tanaka, Kotaro Koyama, Fumihiko Kanzawa, Keiji Wakabayashi, Masahiko Watanabe, Yuko Matsushima-Hibiya
Publikováno v:
Proceedings of the Japan Academy, Series B. 78:305-308
Pierisin-1 is a 98kDa protein known to induce apoptosis in various human carcinoma cell lines with a very wide range of IC50 values. Among those, the cervical carcinoma HeLa cells are the most sensitive, showing IC50 value of 0.043ng/ml. In the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc40f7857a9d4efebb9532c75dc7b80b
https://doi.org/10.2183/pjab.78.305
https://doi.org/10.2183/pjab.78.305
Autor:
Keiji Wakabayashi, Takashi Sugimura, Kotaro Koyama, Takuo Kono, Masahiko Watanabe, Yuko Matsushima-Hibiya, Takashi Kanazawa
Publikováno v:
European Journal of Biochemistry. 267:5742-5750
The cabbage butterfly Pieris rapae contains a strong apoptosis-inducing substance, pierisin, against human cancer cell lines, which is thought to act via ADP-ribosylation. Here we report the purification and cloning of an apoptosis-inducing substance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10828e52bdc0ff9d95ce61110020843
https://doi.org/10.1046/j.1432-1327.2000.01640.x
https://doi.org/10.1046/j.1432-1327.2000.01640.x
Autor:
Takeji Enya, Masayoshi Ohyama, Kotaro Koyama, Hajime Komatsu, Masahiko Watanabe, Takashi Sugimura, Keiji Wakabayashi
Publikováno v:
Proceedings of the Japan Academy, Series B. 76:161-165
We have noticed the presence of cytotoxic activity in the body fluid of a butterfly, Ideopsis similis, in family Danaidae. The cytotoxic principles were purified and identified to be phenanthroindolizidine alkaloids. In addition, the cytotoxic activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb530e8a612766b8acf39d23b22a930
https://doi.org/10.2183/pjab.76.161
https://doi.org/10.2183/pjab.76.161
Autor:
Shoji Fukushima, Takuo Kono, Takashi Sugimura, Masahiko Watanabe, Taketoshi Kishimoto, Keiji Wakabayashi, Kotaro Koyama
Publikováno v:
Cancer Letters. 137:75-81
Pierisin, a protein purified from pupae of the cabbage butterfly, Pieris rapae , exhibits cytotoxic effects against the human gastric cancer TMK-1 cell line, inducing apoptosis. The present study was performed to determine whether pierisin might exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4016ee26a3ad11f7563ad1330c6612
https://doi.org/10.1016/s0304-3835(98)00346-2
https://doi.org/10.1016/s0304-3835(98)00346-2
Publikováno v:
Japanese Journal of Cancer Research : Gann
A substance strongly cytotoxic to human carcinoma cell line TMK-1 has been found in pupae, larvae and adults of the cabbage butterfly, Pieris rapae, and named pierisin. Pierisin was purified from the pupae of P. rapae by ammonium sulfate precipitatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2596e58b249f69bc4fe634e2dc93ff
https://doi.org/10.1111/j.1349-7006.1998.tb03297.x
https://doi.org/10.1111/j.1349-7006.1998.tb03297.x
Autor:
Keizaburo Miki, Kotaro Koyama, Takuo Kono, Mitsuko Masutani, Shigeru Yamazaki, Masahiko Watanabe, Kazunori Koiwai, Keiji Wakabayashi, Takashi Sugimura
Publikováno v:
Japanese Journal of Cancer Research : Gann
Cytotoxic activity in extracts of pupae and adults of various kinds of butterflies and moths was tested in vitro against the human gastric carcinoma cell line, TMK-1, which was chosen as an example of human carcinoma cells. Among the species examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f771a03d96ffe9fa81d88786fdb9ccb5
https://doi.org/10.1111/j.1349-7006.1996.tb03141.x
https://doi.org/10.1111/j.1349-7006.1996.tb03141.x
Autor:
Hiro Wakasugi, Motomichi Gyotoku, Takashi Sugimura, Masaaki Terada, Kotaro Koyama, Masataka Yoshimoto, Setsuo Hirohashi
Publikováno v:
Japanese Journal of Cancer Research : Gann
Tumors developed quite frequently in some of the visceral organs, including spleen and liver, in BALB/c nude mice upon subcutaneously xenografting surgical specimens from five different inflammatory breast cancer patients. All of these tumors develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fbaebbd6f37fa0ad194aa8ade3f4cc
https://doi.org/10.1111/j.1349-7006.1995.tb03025.x
https://doi.org/10.1111/j.1349-7006.1995.tb03025.x