Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Kotaro Hama"'
Autor:
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells. In particul
Externí odkaz:
https://doaj.org/article/304ef5b1eb3c4a3ab19d3dd9ace1fed9
Autor:
Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Colorectal cancer (CRC) is a major cancer, and its precise diagnosis is especially important for the development of effective therapeutics. In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to b
Externí odkaz:
https://doaj.org/article/bfb250236fb14b6cad3a33c992f59d42
Autor:
Kotaro Hama, Yuko Fujiwara, Shigeo Takashima, Yasuhiro Hayashi, Atsushi Yamashita, Nobuyuki Shimozawa, Kazuaki Yokoyama
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-
Externí odkaz:
https://doaj.org/article/7195fa710b5142e4a6d2da324487dc47
Autor:
Kazunari Tanigawa, Yasuhiro Hayashi, Kotaro Hama, Atsushi Yamashita, Kazuaki Yokoyama, Yuqian Luo, Akira Kawashima, Yumi Maeda, Yasuhiro Nakamura, Ayako Harada, Mitsuo Kiriya, Ken Karasawa, Koichi Suzuki
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249184 (2021)
Mycobacterium leprae (M. leprae) is the etiological agent of leprosy, and the skin lesions of lepromatous leprosy are filled with numerous foamy or xanthomatous histiocytes that are parasitized by M. leprae. Lipids are an important nutrient for the i
Externí odkaz:
https://doaj.org/article/9c48a7df449845b6b5b8d1049aeecf86
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8645 (2021)
Adrenoleukodystrophy (X-ALD) is an X-linked genetic disorder caused by mutation of the ATP-binding cassette subfamily D member 1 gene, which encodes the peroxisomal membrane protein, adrenoleukodystrophy protein (ALDP). ALDP is associated with the tr
Externí odkaz:
https://doaj.org/article/d5169c25cfb44ca9aded23ac0338f9d5
Autor:
Ayako Watanabe, Kotaro Hama, Kohei Watanabe, Yuko Fujiwara, Kazuaki Yokoyama, Shigeo Murata, Ryo Takita
Publikováno v:
Angewandte Chemie International Edition. 61
Autor:
Ayako Watanabe, Kotaro Hama, Kohei Watanabe, Yuko Fujiwara, Kazuaki Yokoyama, Shigeo Murata, Ryo Takita
Publikováno v:
Angewandte Chemie. 134
Autor:
Yojiro Hashiguchi, Tamuro Hayama, Tsuyoshi Ozawa, Kazuaki Yokoyama, Keijiro Nozawa, Keiji Matsuda, Kotaro Hama, Yuko Fujiwara
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Colorectal cancer (CRC) is a major cancer, and its precise diagnosis is especially important for the development of effective therapeutics. In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to be elevate
Autor:
Ayako Watanabe, Kotaro Hama, Kohei Watanabe, Yuko Fujiwara, Kazuaki Yokoyama, Shigeo Murata, Ryo Takita
Publikováno v:
Angewandte Chemie International Edition. 61
We describe a concise and reliable protocol for the precisely controlled tetradeuteration of straight-chain fatty acids (FAs) at the α- and β-positions that is generally applicable to a variety of FAs, including trans-FAs, polyunsaturated FAs (PUFA
Autor:
Nobuyuki Shimozawa, Atsushi Yamashita, Kazuaki Yokoyama, Yuko Fujiwara, Kotaro Hama, Yasuhiro Hayashi, Shigeo Takashima
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-