Výsledky vyhledávání - "Kotaro Funato"

Systemic Treatment Patterns With Advanced or Recurrent Non-small Cell Lung Cancer in Japan: A Retrospective Hospital Administrative Database Study

Autor: Sari Mishina, Feng Wang, Kenya Ochi, Shinji Takai, Yuichiro Ohe, Shozo Matsuoka, Kotaro Funato, T. Kim Le

Publikováno v: Clinical therapeutics. 39(6)

Data on the treatment of non-small cell lung cancer (NSCLC) in real-world clinical practice in Japan are limited. This large-scale, retrospective cohort study examined data on patients' characteristics and systemic therapies for advanced or recurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d6e33c4c3b8b643d22a2bab0314b65
https://pubmed.ncbi.nlm.nih.gov/28527959

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The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Autor: Wilhelm G. Dirks, Isabella Bambach, Helmut Bergler, Paul Vesely, Rene G. Ott, Philipp B. Staber, Silvia Schauer, Lukas Kenner, Veronika Sexl, Kotaro Funato, Marshall E. Kadin, Naznin Haq, Andelko Hrzenjak, Werner Linkesch, Gerald Hoefler, Claudia Fuchs, David W. Sternberg

Publikováno v: Blood. 110:3374-3383

Anaplastic large cell lymphomas (ALCLs) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of ALCLs, and among these, 80% have the t(2;5) translocation with NPM-ALK express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31878554e7a07fbd388504a8eaa9f4
https://doi.org/10.1182/blood-2007-02-071258

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Role of Nucleophosmin Mutations in AML

Autor: David W. Sternberg, Kotaro Funato

Publikováno v: Blood. 112:sci-13

Significant advances have been made towards understanding the molecular pathogenesis and prognostic determinants in acute myelogenous leukemia of normal karytype (AMLNK). One of these, somatic mutation within exon 12 of the nucleophosmin gene (NPM1),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eccc430973e60092ce9a4c9543027fe7
https://doi.org/10.1182/blood.v112.11.sci-13.sci-13

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Translational Regulation of Gene Expression by Cytoplasmic Nucleophosmin in AML: A Global Evaluation of RNA’s Differentially Recruited to Polyribosomes

Autor: David W. Sternberg, Greg Khitrov, Yezhou Sun, Weijia Zhang, Jin Chen, Kotaro Funato, Naznin Haq

Publikováno v: Blood. 110:720-720

Nucleophosmin (NPM) exon 12 mutations are found in 50–60 percent of acute myelogenous leukemia (AML) with normal karyotype, and the altered protein (termed NPMc) is relocalized from the nucleolus to the cytoplasm. Multiple functions have been attri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b680ec51bd8db3f52f77f5ed1da3756
https://doi.org/10.1182/blood.v110.11.720.720

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Translational Regulation of Gene Expression by the NPM-ALK Fusion Kinase of Anaplastic Large Cell Lymphoma: A Global Evaluation of Differentially Recruited mRNA’s to Polyribosomes

Autor: Jin Chen, Weijia Zhang, Greg Khitrov, Yezhou Sun, David W. Sternberg, Kotaro Funato, Naznin Haq

Publikováno v: Blood. 108:291-291

The NPM-ALK fusion tyrosine kinase generated by the t(2;5)(p23;q35) chromosomal translocation is present in approximately 50% of anaplastic large cell lymphomas. NPM-ALK is known to play a causal role in the generation of hematopoietic neoplasia, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a23cc6d8a50617faf9aedf3e67eeb7c7
https://doi.org/10.1182/blood.v108.11.291.291

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