Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kota Toshimoto"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1461-1472 (2023)
Abstract The orally available anti‐hepatitis C virus (HCV) drug simeprevir exhibits nonlinear pharmacokinetics at the clinical doses due to saturation of cytochrome P450 (CYP) 3A4 metabolism and organic anion transporting peptide (OATP) 1B mediated
Externí odkaz:
https://doaj.org/article/991453f197e44e0cbb7937706ee24ae5
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)
Metformin is an important antidiabetic drug and often used as a probe for drug–drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism
Externí odkaz:
https://doaj.org/article/1d993496b36543679193b295682659e8
Autor:
Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, Chiyo K. Imamura, Yusuke Tanigawara, Yuichi Sugiyama
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 474-482 (2018)
The Tamoxifen Response by CYP2D6 Genotype‐based Treatment‐1 (TARGET‐1) study (n = 180) was conducted from 2012–2017 in Japan to determine the efficacy of tamoxifen dosing guided by cytochrome P450 2D6 (CYP2D6) genotypes. To predict its outcom
Externí odkaz:
https://doaj.org/article/d321e969e1c84baea31b14f8378e3959
Autor:
Kota Toshimoto, Yuichi Sugiyama, Renato J. Scialis, Nora Lee, Ryota Kikuchi, Hiroyuki Kusuhara, Ralf Lotz, Wooin Lee, Naoki Ishiguro, Xiaoyan Chu, Albert P. Li, Kazuya Maeda, Kiyoe Morita, Aya Kiriake, Manthena V.S. Varma, Takashi Yoshikado, Emi Kimoto, Hong Shen
Publikováno v:
Journal of Pharmaceutical Sciences. 110:376-387
Hepatic uptake clearance has been measured in suspended human hepatocytes (SHH). Plated human hepatocytes (PHH) after short-term culturing are increasingly employed to study hepatic transport driven mainly by its higher throughput. To know pros/cons
Autor:
Wooin Lee, Shigemichi Morita, Kota Toshimoto, Ji Eun Park, Yuichi Sugiyama, Yoshihisa Shitara, Jasminder Sahi
Publikováno v:
Journal of Pharmaceutical Sciences. 110:517-528
Pemafibrate (PMF) is highly albumin-bound (>99.8%) and a substrate for hepatic uptake transporters (OATP1B) and CYP enzymes. Here, we developed a PBPK model of PMF to capture drug-drug interactions (DDI) incurred by cyclosporine (CsA) and rifampicin
Publikováno v:
Journal of Pharmaceutical Sciences. 110:510-516
To identify oral drugs that likely display nonlinear pharmacokinetics due to saturable metabolism by intestinal CYP3A, our previous report using CYP3A substrate drugs proposed an approach using thresholds for the linear index number (LIN3A = dose/Km;
Parameter estimation problems of mathematical models can often be formulated as nonlinear least squares problems. Typically these problems are solved numerically using iterative methods. The local minimiser obtained using these iterative methods usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf51a35a45941c932b874329690dbf8a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478299
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478299
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 396-406 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Metformin is an important antidiabetic drug and often used as a probe for drug-drug interactions (DDIs) mediated by renal transporters. Despite evidence supporting the inhibition of multidrug and toxin extrusion proteins as the likely DDI mechanism,
Autor:
Kazuya Maeda, Shin-ichi Ninomiya, Kota Toshimoto, Shinsuke Aoyama, Wooin Lee, Ryo Fujino, Kenta Hashizume, Yuichi Sugiyama, Kiyomi Ito
Publikováno v:
European Journal of Pharmaceutical Sciences. 125:181-192
The antidiabetic drugs glibenclamide, repaglinide, and nateglinide are well-known substrates for hepatic uptake transporters of the organic anion transporting polypeptide (OATP) family and metabolizing enzymes of the cytochrome P450 (CYP) 2C subfamil
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(4)
Bosentan is a high-affinity antagonist of endothelin receptors and one of the earliest examples for target-mediated drug disposition [a type of nonlinear pharmacokinetics (PKs) caused by saturable target binding]. The previous physiologically based P