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Additional studies on nicotine exposure in horses: Accurate quantification and elimination profiles of potential biomarkers in plasma and urine

Autor: Hideaki Ishii, Mariko Shibuya, Gary Ngai‐Wa Leung, Shozo Yamashita, Shun‐ichi Nagata, Asuka Kushiro, Satoshi Sakai, Kota Toju, Jun Okada, Kazumi Kawasaki, Kanichi Kusano, Isao Kijima‐Suda

Publikováno v: Rapid Communications in Mass Spectrometry. 36

For the purpose of doping control, this is the first report of accurate quantification of four critical structural isomers of nicotine metabolites (trans-3'-hydroxycotinine, cis-3'-hydroxycotinine, 5'-hydroxycotinine, and N'-hydroxymethylnorcotinine)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb92b493db3c40d1b6e96fa2c2415a3d
https://doi.org/10.1002/rcm.9396

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Identification of potential biomarkers in urine and plasma after consumption of tobacco product in horses

Autor: Hideaki Ishii, Gary Ngai‐Wa Leung, Shozo Yamashita, Shun‐ichi Nagata, Asuka Kushiro, Satoshi Sakai, Kota Toju, Jun Okada, Kazumi Kawasaki, Kanichi Kusano, Isao Kijima‐Suda

Publikováno v: Drug testing and analysisREFERENCES. 14(5)

The use of nicotine stimulants in horses is generally banned in horse racing and equestrian sports-accidental consumption of tobacco products is one of the possible causes of nicotine exposure in horses. The authors recently reported a comprehensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7f6cb35be3a4f4b8886f8ebf635ac1
https://pubmed.ncbi.nlm.nih.gov/35195357

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Comprehensive metabolic study of nicotine in equine plasma and urine using liquid chromatography/high-resolution mass spectrometry for the identification of unique biomarkers for doping control

Autor: Hideaki Ishii, Gary Ngai-Wa Leung, Shozo Yamashita, Shun-ichi Nagata, Asuka Kushiro, Satoshi Sakai, Kota Toju, Jun Okada, Kazumi Kawasaki, Kanichi Kusano, Isao Kijima-Suda

Publikováno v: Journal of Chromatography B. 1190:123100

Nicotine is classified as a stimulant, and its use is banned in horse racing and equestrian sports by the International Federation of Horseracing Authorities and the Fédération Équestre Internationale, respectively. Because nicotine is a major alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbec84898e7948c48309b403d27d704f
https://doi.org/10.1016/j.jchromb.2022.123100

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