Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kota Kaneshige"'
Autor:
Zonghua Luo, Jiwei Gu, Kota Kaneshige, Stanley M. Parsons, Hongjun Jin, Yanbo Yu, Joel S. Perlmutter, Hui Liu, Zhude Tu
Publikováno v:
ChemMedChem. 13:1978-1987
Sixteen new sulfur-containing compounds targeting the vesicular acetylcholine transporter (VAChT) were synthesized and assessed for in vitro binding affinities. Enantiomers (-)-(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-(methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982a443da6eb2376b7d4f11b04a4de00
https://doi.org/10.1002/cmdc.201800411
https://doi.org/10.1002/cmdc.201800411
Autor:
Joel S. Perlmutter, Xuyi Yue, Kota Kaneshige, Zhude Tu, Stanley M. Parsons, Xiang Zhang, Hongjun Jin, Zonghua Luo, Hui Liu, Hubert P. Flores
Publikováno v:
Org. Biomol. Chem.. 15:5197-5209
The vesicular acetylcholine transporter (VAChT) is a reliable biomarker for assessing cholinergic dysfunction associated with dementia. We recently reported three new potent and selective carbon-11 labeled VAChT radiotracers. Herein, we report the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e6c9e1eb391576114a1da805894e55
https://doi.org/10.1039/c7ob00854f
https://doi.org/10.1039/c7ob00854f
Autor:
Hongjun Jin, Xuyi Yue, Stanley M. Parsons, Prashanth K. Padakanti, Hui Liu, Hubert P. Flores, Lihai Yu, Xiang Zhang, Kota Kaneshige, Zhude Tu, Joel S. Perlmutter
Publikováno v:
Bioorganic & medicinal chemistry, vol 23, iss 15
Nine fluorine-containing vesicular acetylcholine transporter (VAChT) inhibitors were synthesized and screened as potential PET tracers for imaging the VAChT. Compound 18a was one of the most promising carbonyl-containing benzovesamicol analogs; the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3601589b6deaaa2f1a0978bcff741767
https://doi.org/10.1016/j.bmc.2015.05.058
https://doi.org/10.1016/j.bmc.2015.05.058
Autor:
Yair Hershkovitz, Reeval Segel, Ariella Weinberg-Shukron, Scott Oliphant, Kota Kaneshige, Ming K. Lee, Adi Aran, Tomer Meirson, Stanley M. Parsons, Abraham O. Samson, Sharon Zeligson, Paul Renbaum, Tom Walsh, Mary-Claire King, Suleyman Gulsuner, Ephrat Levy-Lahad
Publikováno v:
Neurology. 88(11)
Objective:To identify the genetic basis of a recessive congenital neurologic syndrome characterized by severe hypotonia, arthrogryposis, and respiratory failure.Methods:Identification of the responsible gene by exome sequencing and assessment of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b44bdbd2881e32faf81abd5bb86b1d
https://pubmed.ncbi.nlm.nih.gov/28188302
https://pubmed.ncbi.nlm.nih.gov/28188302
Publikováno v:
Biochemical and Biophysical Research Communications. 396:278-282
In the previous study, we reported the gene expression for proteins related to the function of 5-hydroxytryptamine (5-HT, serotonin) and elucidated the expression patterns of 5-HT(2) receptor subtypes in mouse osteoblasts. In the present study, we ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09661468686d2ed2a966a3b76efeb1d5
https://doi.org/10.1016/j.bbrc.2010.04.078
https://doi.org/10.1016/j.bbrc.2010.04.078
Autor:
Shawn Scatliffe, Christopher R. McCurdy, Stephanie Chen, Bin Shen, Christopher Lau, Zheng Miao, Ahmad Salehi, Sanjiv S. Gambhir, Kota Kaneshige, Adam J. Shuhendler, Mikael Palner, Lauren Andrews, Frederick T. Chin, Stanley M. Parsons, Michelle L. James, Natasha Arksey
Publikováno v:
EJNMMI research, vol 5, iss 1
EJNMMI Research
EJNMMI Research
Background This study aims to further evaluate the specificity and selectivity of [18F]FTC-146 and obtain additional data to support its clinical translation. Methods The binding of [19F]FTC-146 to vesicular acetylcholine transporter (VAChT) was eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0279df81ac86a4dd59af3e89ad9560
https://escholarship.org/uc/item/8j9269dt
https://escholarship.org/uc/item/8j9269dt
Autor:
Junfeng Li, Zhude Tu, Joel S. Perlmutter, Kota Kaneshige, Xiang Zhang, Hui Liu, Stanley M. Parsons, Hongjun Jin
The loss of cholinergic neurons and synapses relates to the severity of dementia in several neurodegenerative pathologies; and the vesicular acetylcholine transporter (VAChT) provides a reliable biomarker of cholinergic function. We recently characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cba7e16b74e91a0b974b4036ff2f6d
https://europepmc.org/articles/PMC4369186/
https://europepmc.org/articles/PMC4369186/
Publikováno v:
Japanese Psychological Research. 43:91-97
In a water-licking experiment with rats, the effects of the extinction of a first-order conditioned stimulus (CS1) on the suppression of licking established for a second-order conditioned stimulus (CS2) were explored. Extinction of the first-order co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e623ff537a07f965336ba4d3b5a8868f
https://doi.org/10.1111/1468-5884.00164
https://doi.org/10.1111/1468-5884.00164