Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kota Asahina"'
Autor:
Tsuyoshi Matsumura, Kota Asahina, Mariko Yamaoka, Mitsuhiko Kawabata, Rika Ishikawa, Saki Yamauchi, Takahiro Suga, Shin-Ichiro Nitta, Akemi Nagao, Yoshiro Saito, Hitoshi Uchiyama, Keiko Nakai, Koji Arai, Ryoya Goda, Kosuke Saito, Hidehisa Tachiki
Publikováno v:
Bioanalysis. 13(20)
Aim: Although the fit-for-purpose approach has been proposed for validation procedures and acceptance criteria for biomarker assays, practical biomarker assays to facilitate clinical application and regulatory documents on biomarker assays remain lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4497f490959435aaef1d563bf40838a8
https://pubmed.ncbi.nlm.nih.gov/34696608
https://pubmed.ncbi.nlm.nih.gov/34696608
Autor:
Akihiro Nomura, Kojo Arita, Paul D. Crowe, Kazuyuki Hirata, Makoto Shiozaki, Keisuke Ito, Naoki Miyagawa, Yoshiaki Katsuda, Kota Asahina, Hiromasa Hashimoto, Yoshihiro Suwa, Masayuki Kotoku, Haiyan Tao, Yasunori Hase, Yokota Masahiro, Seki Noriyoshi, Fujioka Shingo, Satoki Doi, Tsuyoshi Adachi, Masato Noguchi, Scott M. Thacher, Takayoshi Suzuki, Taku Ikenogami, Takaki Maeba
Publikováno v:
Journal of medicinal chemistry. 62(5)
Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial motifs in conjunction with scaffold hopping was examined, resulting in discovery of the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d47ae0da2d592b09541af2e19b99f9f
https://pubmed.ncbi.nlm.nih.gov/30776227
https://pubmed.ncbi.nlm.nih.gov/30776227
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd5cff234944c1d2a5bfc04f67808993
https://doi.org/10.1016/j.dmpk.2020.04.067
https://doi.org/10.1016/j.dmpk.2020.04.067
Publikováno v:
Journal of Biological Chemistry. 282:33831-33844
The 70-kDa peroxisomal membrane protein (PMP70) is a major component of peroxisomal membranes. Human PMP70 consists of 659 amino acid residues and has six putative transmembrane domains (TMDs). PMP70 is synthesized on cytoplasmic ribosomes and target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4b658ce585407abdfdf82e81ae90e3
https://doi.org/10.1074/jbc.m703369200
https://doi.org/10.1074/jbc.m703369200
Autor:
Naoki Miyagawa, Kota Asahina, Shintaro Hirashima, Scott Thacher, Satoki Doi, Masayuki Kotoku, Yukihiro Nomura, Katsuya Maeda, Shingo Obika, Haiyan Tao, Erin Bradley, Yoshiaki Katsuda, Paul Crowe, Seki Noriyoshi, Ruo Steensma, Takahiro Hata, Tsuyoshi Adachi, Robert Babine, Sakai Takayuki, Makoto Shiozaki, Kojo Arita, Masato Noguchi, Takaki Maeba, Xiaolin Li, Yasunori Hase, Morgan Fenn, Kazuyuki Hirata, Masafumi Kamada, Yusuke Aratsu, Akimi Hori, Takayuki Yamaguchi, Hiromasa Hashimoto
A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness metrics, ligand efficiency (LE) and fraction of sp(3) carbon atoms (Fsp(3)), significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a980bfa040ac0bdac6e9c6c9a5fd8c0
https://europepmc.org/articles/PMC4716592/
https://europepmc.org/articles/PMC4716592/
Autor:
Tsuneo Imanaka, Ronald J.A. Wanders, Hiroaki Kato, Hiroyuki Shibata, Masao Sakaguchi, Yoshinori Kashiwayama, Kota Asahina, Masashi Morita, Ania C. Muntau, Adelbert A. Roscher, Nobuyuki Shimozawa
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1746(2), 116-128. Elsevier
Pex19p is a protein required for the peroxisomal membrane synthesis. The 70-kDa peroxisomal membrane protein (PMP70) is synthesized on free cytosolic ribosomes and then inserted posttranslationally into peroxisomal membranes. Pex19p has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa0adf242cb9d702f1ba06e8715ad3f
Autor:
Dzmitry G. Kostsin, Tsuneo Imanaka, Kota Asahina, Asaka Lee, Yoshinori Kashiwayama, Kojiro Takanashi, Kazufumi Yazaki, Takumi Okamoto, Kosuke Kawaguchi, Masashi Morita
Publikováno v:
Biochemical and biophysical research communications. 453(3)
In mammals, four ATP-binding cassette (ABC) proteins belonging to subfamily D have been identified. ABCD1–3 possesses the NH 2 -terminal hydrophobic region and are targeted to peroxisomes, while ABCD4 lacking the region is targeted to the endoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a91e4ee494f7c92f396aca93f841d8
https://pubmed.ncbi.nlm.nih.gov/25301552
https://pubmed.ncbi.nlm.nih.gov/25301552