Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kosuke Yokobori"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Phenobarbital (PB) is an archetypal substance used as a mouse hepatocellular carcinoma (HCC) promotor in established experimental protocols. Our previous results showed CAR is the essential factor for PB induced HCC promotion. Subsequent studies sugg
Externí odkaz:
https://doaj.org/article/dedd1b54740847bab9640658a3ba00f5
Autor:
Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding doma
Externí odkaz:
https://doaj.org/article/f47bed05def941a5a8f9466a17d42c03
Publikováno v:
Biochemical and Biophysical Research Communications. 615:75-80
Nuclear receptor Pregnane X Receptor (PXR; NR1I2) has transcriptional regulation functions for energy homeostasis in the liver. Mouse PXR has a conserved phosphorylation motif at serine 347 (serine 350 in humans) within the ligand-binding domain. PXR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6e4115f340da6bc2e1e14bd5b5cf2a
https://doi.org/10.1016/j.bbrc.2022.05.055
https://doi.org/10.1016/j.bbrc.2022.05.055
Publikováno v:
Curr Opin Struct Biol
Cellular identity and physiologic function in mammary epithelial cells and in many breast cancers flow from the action of a network of master transcriptional regulators including Estrogen Receptor alpha, GATA3 and FOXA1. The last decade has seen the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa0d37856a9f49cb6e843023b7ab1ed
https://doi.org/10.1016/j.sbi.2021.05.015
https://doi.org/10.1016/j.sbi.2021.05.015
Autor:
Kosuke Yokobori, Masahiko Negishi
Publikováno v:
Biochemical and biophysical research communications. 639
Androgen receptor, which regulates diverse biological processes for cell fate decisions, forms a homodimer in the cytoplasm and is monomerized by activation for nuclear translocation. Ser815 phosphorylated AR is expressed in mature prostates, with le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b427290290126803b3650f93c09ac
https://pubmed.ncbi.nlm.nih.gov/36470072
https://pubmed.ncbi.nlm.nih.gov/36470072
Autor:
Kosuke Yokobori, Shih Heng Chen, Sawako Shindo, Manas K. Ray, Saki Gotoh, Kiyoshi Nagata, Masahiko Negishi, Jennifer Martinez, Hao Hu, Jau-Shyong Hong, Rick Moore
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543990fb3c4398e7addde61c7868e6a
http://link.springer.com/article/10.1186/s12964-020-00578-x
http://link.springer.com/article/10.1186/s12964-020-00578-x
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
The androgen receptor (AR) regulates male sexual development. We have now investigated AR homodimerization, hormone-dependent monomerization and nuclear translocation in PC-3 and COS-1 cells, by utilizing mutations associated with the androgen insens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30823d53273365845126ac5ef82a41d
http://link.springer.com/article/10.1038/s41598-019-53139-9
http://link.springer.com/article/10.1038/s41598-019-53139-9
Autor:
Kosuke Yokobori, Masahiko Negishi
Publikováno v:
Journal of the Endocrine Society
Androgen receptor (AR) regulates male sexual development and maintenance. AR forms a homodimer in the cytoplasm and monomerizes following hormonal activation, translocating to the nucleus in Cos-1 cells (Shizu et al. Scientific reports. 2019). Utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22cf5e8fc75dafe1d699d10367ccf23
http://europepmc.org/articles/PMC7207685
http://europepmc.org/articles/PMC7207685
Publikováno v:
Bioscience Reports
Vaccinia-related kinase 1 (VRK1) is a chromatin-associated Ser-Thr kinase that regulates numerous downstream factors including DNA repair as well as stress factors c-Jun and p53. Both c-Jun and p53 are phosphorylated at Ser63 and Thr18, respectively,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b5f57b7e2ebec96bc8cd8ca339f4cc
https://doi.org/10.1042/bsr20200498
https://doi.org/10.1042/bsr20200498
Autor:
Yoshitaka Sekine, Sumihito Nobusawa, Kosuke Yokobori, Yuki Kawasaki, Masahiko Negishi, Satoru Kakizaki, Toshiyuki Sakaki
Publikováno v:
Biochemical Pharmacology. 194:114794
Androgen is beneficial for the prostate with normal functions but creates a risk for prostate cancer progression. How androgen receptor (AR) mediates these various actions of androgen remains elusive. AR conserves a phosphorylation motif within its l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a776b9e7791e04ae182517e9561f1a53
https://doi.org/10.1016/j.bcp.2021.114794
https://doi.org/10.1016/j.bcp.2021.114794