A Two-State Model Describes the Temperature-Dependent Conformational Equilibrium in the Alanine-Rich Domains in Elastin

Autor: Kosuke Ohgo, Kristin K. Kumashiro, Jhonsen Djajamuliadi

Publikováno v: The journal of physical chemistry. B. 124(41)

Elastin is the insoluble elastomeric protein that provides extensibility and resilience to vertebrate tissues. Limited high-resolution structural data for elastin are notably complex. To access this information, this protein is considered in the simp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7d65ed598fc13ce3aa2b04d5175ab5
https://pubmed.ncbi.nlm.nih.gov/32936634

Targeting Alanines in the Hydrophobic and Cross-Linking Domains of Native Elastin with Isotopic Enrichment and Solid-State NMR Spectroscopy

Autor: Jhonsen Djajamuliadi, Kosuke Ohgo, Kristin K. Kumashiro

Publikováno v: Macromolecules. 51:2157-2168

Details of elastin’s complex conformational and dynamic heterogeneity were acquired from one- and two-dimensional solid-state nuclear magnetic resonance (ssNMR) experiments on hydrated elastin that is isotopically enriched at its alanines. Elastin�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07a6e9a617ee939f2a23451eb49a8bb8
https://doi.org/10.1021/acs.macromol.7b02617

Tropoelastin Implants That Accelerate Wound Repair

Autor: Yiwei Wang, Francia Garces-Suarez, Suzanne M. Mithieux, Elizabeth A. Carter, Alan Riboldi-Tunnicliffe, Kosuke Ohgo, Clair Baldock, Kristin K. Kumashiro, Le-Ping Yan, Wojciech Chrzanowski, Anthony S. Weiss, Christina Limantoro, Glenn A. Edwards, David Cookson, Kekini V. Kuppan, Behnaz Aghaei-Ghareh-Bolagh, Zhe Li, Peter K.M. Maitz

Publikováno v: Mithieux, S M, Aghaei-Ghareh-Bolagh, B, Yan, L, Kuppan, K V, Wang, Y, Garces-Suarez, F, Li, Z, Maitz, P K, Carter, E A, Limantoro, C, Chrzanowski, W, Cookson, D, Riboldi-Tunnicliffe, A, Baldock, C, Ohgo, K, Kumashiro, K K, Edwards, G & Weiss, A S 2018, ' Tropoelastin Implants That Accelerate Wound Repair ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201701206

A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feee0f12f22fd1e4884b63dc90ee0e67
https://pubmed.ncbi.nlm.nih.gov/29450975

Wideline Separation (WISE) NMR of Native Elastin

Autor: Kosuke Ohgo, Allen K. Onizuka, Taeko Muroi, Walter P. Niemczura, Kristin K. Kumashiro

Publikováno v: Macromolecules. 42:8899-8906

Native elastin is an insoluble, amorphous (noncrystalline) protein with significant hydrophobic character. As its name suggests, the elasticity of blood vessels and other tissue types in vertebrates originates from this protein. We have previously sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90ff4a49f432513d3378fc5cac5286e3
https://doi.org/10.1021/ma901604m

Comparative study of silk fibroin porous scaffolds derived from salt/water and sucrose/hexafluoroisopropanol in cartilage formation

Autor: Shinichi Terada, Tetsuo Asakura, Kumiko Makaya, Kosuke Ohgo

Publikováno v: Journal of Bioscience and Bioengineering. 108:68-75

The purpose of this study is to create a new silk fibroin scaffold with sufficient three-dimensional morphology and porous structure for cartilage formation. We have applied sucrose particles sized around 300 to 500 μm as porogens compared to equal-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74c6a3a4428487d2c4c42048b87c172
https://doi.org/10.1016/j.jbiosc.2009.02.015