Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kosuke Kanuma"'
Autor:
Kaho Arikawa, Seiken Tokura, Ryo Takahashi, Kosuke Kanuma, Tomoko Abe-Kumasaka, Hiroyuki Sugiyama, Toru Yamaguchi-Sasaki, Yutaka Sugaya, Yuya Ogata, Takanori Kawaguchi, Ippei Yoshida, Kanako Iwakiri
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This e
Autor:
Yuya Ogata, Jun Kurosaka, Ryo Takahashi, Yutaka Sugaya, Eiji Tanigawa, Hiroyuki Sugiyama, Kosuke Kanuma, Kanako Iwakiri, Toru Yamaguchi-Sasaki, Tomoko Abe-Kumasaka, Naoko Ueda-Yonemoto, Yunoshin Tamura, Takanori Kawaguchi, Tsuyoshi Busujima
Publikováno v:
Chemical and Pharmaceutical Bulletin. 68:345-362
Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections and a significant pathogen for both adults and children. Although two drugs have been approved for the treatment of RSV infections, the low thera
Autor:
Risa Kurimoto-Tsuruta, Seiken Tokura, Kosuke Kanuma, Yuya Ogata, Tamaoki Tomokazu, Hiroyuki Sugiyama, Takanori Kawaguchi, Kaho Arikawa, Takeuchi Tomoki, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Atsushi Okada, Ippei Yoshida, Tomoko Abe-Kumasaka, Yutaka Sugaya, Ryo Takahashi, Mitsukane Yoshinaga
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115818
The development of effective respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors against both wild-type and the D486N-mutant F protein is urgently required. We recently reported a 15-membered macrocyclic pyrazolo[1,5-a]pyrimi
Autor:
Mariko Nishiguchi, Michihiko Iijima, Toshiharu Shimazaki, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Akie Ito, Kosuke Kanuma
Publikováno v:
Pharmacology Biochemistry and Behavior. 135:154-168
Melanin-concentrating hormone receptor 1 (MCH1 receptor) is known to be involved in the control of mood and stress, in addition to the regulation of feeding. Here, we report further evidence that the blockade of the MCH1 receptor exhibits antidepress
Publikováno v:
Recent Patents on CNS Drug Discovery. 5:23-34
The glutamate hypothesis of schizophrenia suggests that hypofunction of N-methyl-D-aspartate (NMDA) receptors may be critical for schizophrenic symptoms; therefore, pharmacological approaches that enhance NMDA function may be beneficial for the treat
Autor:
Bryan A. Kramer, Kevin Whelan, Yoshinori Sekiguchi, Shigeyuki Chaki, Pureza Vallar, Michael Morgan, Graeme Semple, Thuy-Anh Tran, William Thomsen, Dipanjan Sengupta, Juyi Choi, Debbie Hsu, Andrew J. Grottick, Kosuke Kanuma, Erin K. Hauser, Ning Zou, Martin Casper, Sangdon Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6166-6171
A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was not
Autor:
Bill Thomsen, Mariko Nishiguchi, Debbie Hsu, Graeme Semple, Katsunori Omodera, Bryan A. Kramer, Kosuke Kanuma, Takeo Funakoshi, Martin Casper, Thuy-Anh Tran, Yoshinori Sekiguchi, Shigeyuki Chaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3853-3856
The optimization of a series of 4-(dimethylamino)quinazoline antagonists of the melanin-concentrating hormone receptor 1 (MCH-R1) is described. The combination of the elaboration of both the linker portion and the terminal phenyl ring provided N-(cis
Autor:
Kosuke Kanuma, Shigeyuki Chaki
Publikováno v:
Drug Discovery for Psychiatric Disorders ISBN: 9781849733656
Numerous neuropeptides have recently attracted interest as novel targets for drug discovery for the treatment of depression and anxiety based on the important roles that these proteins play in regulating stress responses. Neuropeptides exert their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aa3cc15997220f988700c6a48fbf212
https://doi.org/10.1039/9781849734943-00300
https://doi.org/10.1039/9781849734943-00300
Autor:
Kosuke Kanuma, Yoshinori Sekiguchi, Shigeyuki Chaki, Kazuaki Takamori, Tsutomu Suzuki, Sayoko Suetake-Koga, Toyohiko Kikuchi, Toshio Honda, Toshiharu Shimazaki, Yoshimitsu Matsui
Publikováno v:
Pharmacology, biochemistry, and behavior. 84(1)
The analgesic activity and side effect liabilities of a novel NR2B antagonist, 7-hydroxy-6-methoxy-2-methyl-1-(2-(4-(trifluoromethyl)phenyl)ethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (HON0001) were investigated. HON0001 inhibited [3H]MK-801
Autor:
Junichi Yamaguchi, Katsunori Omodera, Takeo Funakoshi, Yoshinori Sekiguchi, Shigeyuki Chaki, Izumi Iida, Kosuke Kanuma, Graeme Semple, Yasuko Nagase, Mariko Nishiguchi, Thuy-Anh Tran
Publikováno v:
Bioorganicmedicinal chemistry. 14(10)
The optimization of the distance between two key pharmacophore features within our first hit compounds 1a and 2a led to the identification of a new class of potent non-peptidic antagonists for the MCH-R1, based around 4-amino-2-cyclohexylaminoquinazo