Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Kostrzewa, R. M."'
Publikováno v:
ETSU Faculty Works.
There is now considerable evidence that both schizophrenia and affective disorders have their origin at least in part in events that occur during early pre- and post-natal development. In the case of schizophrenia, many observations, for example, inc
Externí odkaz:
https://dc.etsu.edu/etsu-works/19052
Publikováno v:
ETSU Faculty Works.
Summary. Despite its being the most efficacious drug for symptom reversal in Parkinson's disease (PD), there is concern that chronic levodopa (L-DOPA) treatment may be detrimental. In this paper we review the potential for L-DOPA to 1) autoxidize fro
Externí odkaz:
https://dc.etsu.edu/etsu-works/19026
Publikováno v:
ETSU Faculty Works.
The perinate is particularly risk-prone to chemical species which have the potential of inducing neuronal apoptosis or necrosis and thereby adversely altering development of the brain, to produce life-long functional and behavioral deficits. This pap
Externí odkaz:
https://dc.etsu.edu/etsu-works/18986
Autor:
Kostrzewa, R. M., Segura-Aguilar, J.
Publikováno v:
ETSU Faculty Works.
SNpc neurons are uniquely at risk from damage by a variety of ROS, including catechol-quinones formed from autoxidation of DA; as well as Tyr O, TyrOOH, H2O2O-.2, NO., HONOO-, and HO.. The high content of Fe2+ in SNpc neurons further promotes HO. for
Externí odkaz:
https://dc.etsu.edu/etsu-works/18987
Publikováno v:
ETSU Faculty Works.
The intracellular second messenger nitric oxide (NO) is implicated in a variety of physiological functions, including release and uptake of dopamine (DA). In the described study, in vivo microdialysis and differential pulse voltammetric techniques we
Externí odkaz:
https://dc.etsu.edu/etsu-works/18862
http://www.jpp.krakow.pl/journal/archive/06_02/pdf/251_06_02_article.pdf
http://www.jpp.krakow.pl/journal/archive/06_02/pdf/251_06_02_article.pdf
Publikováno v:
ETSU Faculty Works.
Factors that confer predisposition and vulnerability for alcoholism and other substance abuse disorders may be described usefully within the gene-environment interplay framework. Thus, it is postulated that heritability provides a major contribution
Externí odkaz:
https://dc.etsu.edu/etsu-works/18850
Publikováno v:
ETSU Faculty Works.
A multitude of factors, that either singly, interactively, or sequentially influence the gene-environment interplay in affective and dementia states, include several phases of neurodevelopmental liability in both humans and laboratory animals. Geneti
Externí odkaz:
https://dc.etsu.edu/etsu-works/18847
Publikováno v:
ETSU Faculty Works.
L-Dihydroxyphenylalanine (L-DOPA), the anti-parkinsonian drug affording the greatest symptomatic relief of parkinsonian symptoms, is still misunderstood in terms of its neurotoxic potential and the mechanism by which generated dopamine (DA) is able t
Externí odkaz:
https://dc.etsu.edu/etsu-works/18494