Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kostomiris DH"'
Autor:
Ken Hirata, Sungjun Beck, Hong Wang, Tat, Pavla Fajtová, Balachandra Chenna, Daniel C Maneval, Brett L. Hurst, Hsu J, Thomas D. Meek, Ardala Katzfuss, Anthony J. O’Donoghue, Frank M. Raushel, Li Li, Chien-Te K Tseng, Klaudia I. Kocurek, Kostomiris Dh, Aaron F. Carlin, Danielle E. Skinner, Felix W Frueh, Miriam A. Giardini, Jiyun Zhu, Zane W. Taylor, Aleksandra Drelich, Drake M. Mellott, de Siqueira-Neto Jl, Laura Beretta, James H. McKerrow, Alex E. Clark
Publikováno v:
bioRxiv
ACS Chemical Biology
article-version (status) pre
article-version (number) 2
ACS Chemical Biology
article-version (status) pre
article-version (number) 2
K777 is a di-peptide analog that contains an electrophilic vinyl-sulfone moiety and is a potent, covalent inactivator of cathepsins. Vero E6, HeLa/ACE2, Caco-2, A549/ACE2, and Calu-3, cells were exposed to SARS-CoV-2, and then treated with K777. K777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e9f9624831d65f564f679a6c488aa4
https://europepmc.org/articles/PMC7605553/
https://europepmc.org/articles/PMC7605553/
Autor:
Edwardes LV; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Caswell SJ; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Giurrandino M; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Zhai X; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Boston, Massachusetts 02210, United States., Gohlke A; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Kostomiris DH; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Boston, Massachusetts 02210, United States., Pollard HK; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Pflug A; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hamm GR; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Jervis KV; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Clarkson PN; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Syson K; Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
Publikováno v:
Biochemistry [Biochemistry] 2022 Sep 20; Vol. 61 (18), pp. 1974-1987. Date of Electronic Publication: 2022 Sep 07.
Autor:
Mellott DM, Tseng CT; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Drelich A; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Fajtová P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic., Chenna BC, Kostomiris DH, Hsu J; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Zhu J, Taylor ZW, Kocurek KI, Tat V; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States., Katzfuss A, Li L, Giardini MA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Skinner D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Hirata K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Yoon MC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Beck S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Carlin AF; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California 92037, United States., Clark AE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Beretta L; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Maneval D, Hook V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States., Meek TD, McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.
Publikováno v:
ACS chemical biology [ACS Chem Biol] 2021 Apr 16; Vol. 16 (4), pp. 642-650. Date of Electronic Publication: 2021 Mar 31.
Autor:
Mellott DM; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Tseng CT; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Drelich A; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Fajtová P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic., Chenna BC; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Kostomiris DH; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Hsu J; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Zhu J; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Taylor ZW; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843.; Current address: Biological Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA 99353., Tat V; Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas, 77755-1001., Katzfuss A; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Li L; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Giardini MA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Skinner D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Hirata K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Beck S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Carlin AF; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA., Clark AE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Beretta L; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Maneval D; Selva Therapeutics, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Frueh F; Selva Therapeutics, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Hurst BL; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Wang H; Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, Utah, 84322., Kocurek KI; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., Raushel FM; Department of Chemistry, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., de Siqueira-Neto JL; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA., Meek TD; Department of Biochemistry and Biophysics, Texas A&M University, 301 Old Main Drive, College Station, Texas 77843., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.
Publikováno v:
BioRxiv : the preprint server for biology [bioRxiv] 2020 Oct 30. Date of Electronic Publication: 2020 Oct 30.