Structure of high-risk papillomavirus type 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation

Autor: Conrady, M. (Marcel Chris), Suarez, I. (Irina), Gogl, G. (Gergo), Frecot, D. (Desiree Isabella), Bonhoure, A. (Anna), Kostmann, C. (Camille), Cousido-Siah, A. (Alexandra), Mitschler, A. (André), Lim, J. (JiaWen), Masson, M. (Murielle), Iftner, T. (Thomas), Stubenrauch, F. (Frank), Travé, G. (Gilles), Simon, C. (Claudia), Banks, L. (Lawrence) (editor)

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2020, ⟨10.1128/jvi.00730-20⟩
J Virol
Journal of Virology, American Society for Microbiology, 2020, 95 (2), ⟨10.1128/JVI.00730-20⟩

The degradation of p53 is a hallmark of high-risk human papillomaviruses (HPVs) of the alpha genus and HPV-related carcinogenicity. The oncoprotein E6 forms a ternary complex with the E3 ubiquitin ligase E6-associated protein (E6AP) and tumor suppres

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https://hal.archives-ouvertes.fr/hal-03058435