Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Kostja, Renko"'
Autor:
Asya Kadic, Patricia Oles, Benjamin Christian Fischer, Anne Elisabeth Reetz, Boubacar Sidiki Sylla, Katreece Feiertag, Vera Ritz, Tanja Heise, Philip Marx-Stoelting, Tewes Tralau, Kostja Renko, Marize de Lourdes Marzo Solano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alterations in thyroid hormones (TH) and thyroid-stimulating hormone levels are frequently found following exposure to chemicals of concern. Dysregulation of TH levels can severely perturb physiological growth, metabolism, differentiation, h
Externí odkaz:
https://doaj.org/article/59660257376f40a694545e90de68a965
Autor:
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Alexandra Heinrich, Josef Köhrle, Yoshiyuki Henning
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionAbout 10% of all rodent species have evolved a subterranean way of life, although life in subterranean burrows is associated with harsh environmental conditions that would be lethal to most animals living above ground. Two key adaptations
Externí odkaz:
https://doaj.org/article/5286e23d0814451d927921f629cb686c
Autor:
Patricia Gerhardt, Sabine Begall, Caroline Frädrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Köhrle, Eddy Rijntjes, Yoshiyuki Henning
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract African mole-rats are subterranean rodents inhabiting underground burrows. This habitat entails risks of overheating, hypoxia, and scarce food availability. Consequently, many subterranean species have evolved low basal metabolism and low bo
Externí odkaz:
https://doaj.org/article/a34ab3b7d48041248e07b0f0681a47e6
Autor:
Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana I. Cañas-Portilla, Frédéric Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandise, Jane E. Morthorst, Nikolai Georgiev Nikolov, Ana C. V. E. Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H. Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measurin
Externí odkaz:
https://doaj.org/article/11318ef2537f459fb447b21949bc2674
Autor:
Julian Hackler, Kamil Demircan, Thilo Samson Chillon, Qian Sun, Nino Geisler, Michael Schupp, Kostja Renko, Lutz Schomburg
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102592- (2023)
Introduction: Selenium (Se) is an essential trace element that exerts its effects mainly as the proteinogenic amino acid selenocysteine within a small set of selenoproteins. Among all family members, selenoprotein P (SELENOP) constitutes a particular
Externí odkaz:
https://doaj.org/article/4996bb3c5e4f4f57a294c91b052480ee
Autor:
Olena Mackert, Eva Katrin Wirth, Rongwan Sun, Jennifer Winkler, Aoxue Liu, Kostja Renko, Séverine Kunz, Joachim Spranger, Sebastian Brachs
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101563- (2022)
Objective: Alterations in mitochondrial function play an important role in the development of various diseases, such as obesity, insulin resistance, steatohepatitis, atherosclerosis and cancer. However, accurate assessment of mitochondrial respiratio
Externí odkaz:
https://doaj.org/article/8505d120091843a08eabbb00618e365e
Autor:
Kostja Renko, Helena Kerp, Janina Pape, Eddy Rijntjes, Tanja Burgdorf, Dagmar Führer, Josef Köhrle
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
In animal studies, both in basic science and in toxicological assessment of potential endocrine disruptors, the state of the thyroid hormone (TH) axis is often described and defined exclusively by the concentrations of circulating THs and TSH. Althou
Externí odkaz:
https://doaj.org/article/9422fa19804b4489ba7aa34a691753cc
Autor:
Annelie Blumrich, Georg Vogler, Sandra Dresen, Soda Balla Diop, Carsten Jaeger, Sarah Leberer, Jana Grune, Eva K. Wirth, Beata Hoeft, Kostja Renko, Anna Foryst-Ludwig, Joachim Spranger, Stephan Sigrist, Rolf Bodmer, Ulrich Kintscher
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102288- (2021)
Summary: The cross talk between adipose tissue and the heart has an increasing importance for cardiac function under physiological and pathological conditions. This study characterizes the role of fat body lipolysis for cardiac function in Drosophila
Externí odkaz:
https://doaj.org/article/44d9abc00f5c4236a1b2cc5ddfbcc027
Autor:
Maria Schwarz, Kristina Lossow, Katja Schirl, Julian Hackler, Kostja Renko, Johannes Florian Kopp, Tanja Schwerdtle, Lutz Schomburg, Anna Patricia Kipp
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101746- (2020)
Selenium and copper are essential trace elements for humans, needed for the biosynthesis of enzymes contributing to redox homeostasis and redox-dependent signaling pathways. Selenium is incorporated as selenocysteine into the active site of redox-rel
Externí odkaz:
https://doaj.org/article/a97805807cf64c6ea061e348442ddc7a
Autor:
Josef Köhrle, Ina Lehmphul, Maik Pietzner, Kostja Renko, Eddy Rijntjes, Keith Richards, João Anselmo, Mark Danielsen, Jacqueline Jonklaas
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2020)
Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolit
Externí odkaz:
https://doaj.org/article/67a615df115746a7ad0c5b9317b970bb