Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole.

Autor: Cole, Susan¹ (AUTHOR) susan.cole@mhra.gov.uk, Malamatari, Maria¹ (AUTHOR), Butler, Andrew¹ (AUTHOR), Arshad, Mahnoor² (AUTHOR), Kerwash, Essam¹ (AUTHOR)

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Nov2024, Vol. 13 Issue 11, p1990-2001. 12p.

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review.

Autor: Litou C; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany., Effinger A; Department of Pharmacy and Pharmacology, Faculty of Science, University of Bath, Bath, UK., Kostewicz ES; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany., Box KJ; Pion Inc. (UK) Ltd., Forest Row, East Sussex, UK., Fotaki N; Department of Pharmacy and Pharmacology, Faculty of Science, University of Bath, Bath, UK., Dressman JB; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany.

Publikováno v: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2019 Apr; Vol. 71 (4), pp. 643-673. Date of Electronic Publication: 2018 Jul 30.

In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review.

Autor: O'Dwyer PJ; Pion Inc. (UK) Ltd., Forest Row, East Sussex, UK.; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece., Litou C; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany., Box KJ; Pion Inc. (UK) Ltd., Forest Row, East Sussex, UK., Dressman JB; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany., Kostewicz ES; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany., Kuentz M; University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland., Reppas C; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece.

Publikováno v: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2019 Apr; Vol. 71 (4), pp. 536-556. Date of Electronic Publication: 2018 Jun 28.

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug.

Autor: Pathak SM; Simcyp Limited (A Certara Company) , Blades Enterprise Centre, John Street, Sheffield, S2 4SU, United Kingdom., Ruff A; Department of Pharmaceutical Technology, Johann Wolfgang Goethe University , Max-von-Laue-Strasse 9, Frankfurt am Main 60438, Germany., Kostewicz ES; Department of Pharmaceutical Technology, Johann Wolfgang Goethe University , Max-von-Laue-Strasse 9, Frankfurt am Main 60438, Germany., Patel N; Simcyp Limited (A Certara Company) , Blades Enterprise Centre, John Street, Sheffield, S2 4SU, United Kingdom., Turner DB; Simcyp Limited (A Certara Company) , Blades Enterprise Centre, John Street, Sheffield, S2 4SU, United Kingdom., Jamei M; Simcyp Limited (A Certara Company) , Blades Enterprise Centre, John Street, Sheffield, S2 4SU, United Kingdom.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2017 Dec 04; Vol. 14 (12), pp. 4305-4320. Date of Electronic Publication: 2017 Aug 25.

Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling.

Autor: Ruff A; Institute of Pharmaceutical Technology, Goethe University, Frankfurt/Main, Germany., Fiolka T; Institute of Pharmaceutical Technology, Goethe University, Frankfurt/Main, Germany., Kostewicz ES; Institute of Pharmaceutical Technology, Goethe University, Frankfurt/Main, Germany. Electronic address: kostewicz@em.uni-frankfurt.de.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2017 Mar 30; Vol. 100, pp. 42-55. Date of Electronic Publication: 2016 Dec 21.