Dispersible amyloid beta protein oligomers, protofibrils, and fibrils in symptomatic AD, preclinical AD and control brains

Autor: Rijal Upadhaya, Ajeet, Kosterin, Irina, Walter, Jochen, Kumar, Sathish, Fändrich, Marcus, Rudolf Thal, Dietmar

Publikováno v: 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20120912-20120915; Erlangen; DOC12dgnnPP4.1 /20120911/

Alzheimer's disease (AD) is characterized by the deposition of the amyloid beta (Aβ) protein in the brain. Various forms of Ab aggregates have been described in the AD brains. Soluble Ab protein aggregates have been discussed as toxic agents. Disper

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Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease.

Autor: Rijal Upadhaya, Ajeet, Kosterin, Irina, Kumar, Sathish, von Arnim, Christine A. F., Yamaguchi, Haruyasu, Fändrich, Marcus, Walter, Jochen, Thal, Dietmar Rudolf

Publikováno v: Brain: A Journal of Neurology; Mar2014, Vol. 137 Issue 3, p887-903, 17p