Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kostas Paschos"'
Autor:
Christine T Styles, Quentin Bazot, Gillian A Parker, Robert E White, Kostas Paschos, Martin J Allday
Publikováno v:
PLoS Biology, Vol 15, Iss 8, p e2001992 (2017)
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. If the cells are infected ex vivo, they are transformed into continuously proliferating lymphoblastoid cell lines (LCLs) that carry EBV DNA as extra-ch
Externí odkaz:
https://doaj.org/article/5d007c99841c4a07b1e2e58730427abe
Publikováno v:
Pathogens, Vol 7, Iss 1, p 31 (2018)
The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A, EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long latency of Epstein–Barr virus (EBV) in the worldwide human population. EBNA3-me
Externí odkaz:
https://doaj.org/article/fde69883621d480c8a85b61d2b010bf2
Autor:
Jens S Kalchschmidt, Adam C T Gillman, Kostas Paschos, Quentin Bazot, Bettina Kempkes, Martin J Allday
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005383 (2016)
It is well established that Epstein-Barr virus nuclear antigen 3C (EBNA3C) can act as a potent repressor of gene expression, but little is known about the sequence of events occurring during the repression process. To explore further the role of EBNA
Externí odkaz:
https://doaj.org/article/e8f97bf739ab4b8fb015b4ca2ffdc8f3
Autor:
Quentin Bazot, Kostas Paschos, Lenka Skalska, Jens S Kalchschmidt, Gillian A Parker, Martin J Allday
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005031 (2015)
We show that two host-encoded primary RNAs (pri-miRs) and the corresponding microRNA (miR) clusters--widely reported to have cell transformation-associated activity--are regulated by EBNA3A and EBNA3C. Utilising a variety of EBV-transformed lymphobla
Externí odkaz:
https://doaj.org/article/5df2e90ec487485f89827bb3463b05d7
Autor:
Lenka Skalska, Robert E. White, Gillian A. Parker, Ernest Turro, Alison J. Sinclair, Kostas Paschos, Martin J. Allday
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3 (2013)
Externí odkaz:
https://doaj.org/article/25147c91da714e85910512111daf0f46
Autor:
Lenka Skalska, Robert E White, Gillian A Parker, Ernest Turro, Alison J Sinclair, Kostas Paschos, Martin J Allday
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003187 (2013)
To explore the role of p16(INK4a) as an intrinsic barrier to B cell transformation by EBV, we transformed primary B cells from an individual homozygous for a deletion in the CDKN2A locus encoding p16(INK4a) and p14(ARF). Using recombinant EBV-BAC vir
Externí odkaz:
https://doaj.org/article/28b56d54882a42acada95ed3eb0c789a
Autor:
Kostas Paschos, Paul Smith, Emma Anderton, Jaap M Middeldorp, Robert E White, Martin J Allday
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000492 (2009)
In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the pro-apoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the EBV nuclear proteins EBNA3A
Externí odkaz:
https://doaj.org/article/30d919b9764d4eed928add5f6393bfdb
Autor:
Irene Bassano, Simon Watson, Cinzia Malangone, Christopher L. Pinder, Kostas Paschos, Hannah M. Cheeseman, Robin J. Shattock, Paul Kellam
HIV (human immunodeficiency virus) is a virus that infects different cell types in the immune system. While different monoclonal antibodies have been identified, because of the antigenic diversity of HIV, defining broad neutralising antibodies (bnAbs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59cb68e96bb914b862cb7610d43b402
https://doi.org/10.1101/2023.04.18.23288724
https://doi.org/10.1101/2023.04.18.23288724
Autor:
Christine T. Styles, Kostas Paschos, Gillian A. Parker, Martin J. Allday, Quentin Bazot, Robert E. White
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 8, p e2001992 (2017)
PLoS Biology, Vol 15, Iss 8, p e2001992 (2017)
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. If the cells are infected ex vivo, they are transformed into continuously proliferating lymphoblastoid cell lines (LCLs) that carry EBV DNA as extra-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c005f0f5215631b0419423a48884c64
http://hdl.handle.net/10044/1/52043
http://hdl.handle.net/10044/1/52043
Autor:
Kostas, Paschos, Quentin, Bazot, Guiyi, Ho, Gillian A, Parker, Jonathan, Lees, Geraint, Barton, Martin J, Allday
Publikováno v:
Nucleic Acids Research
ChIP-seq performed on lymphoblastoid cell lines (LCLs), expressing epitope-tagged EBNA3A, EBNA3B or EBNA3C from EBV-recombinants, revealed important principles of EBNA3 binding to chromatin. When combined with global chromatin looping data, EBNA3-bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e1689a50ddc931368a05c3b880b4a80
https://pubmed.ncbi.nlm.nih.gov/27903901
https://pubmed.ncbi.nlm.nih.gov/27903901