Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kostas Gavardinas"'
Autor:
Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A Reidy, Joseph V Haas, Yanping Xu, Mark C Kowala, Prabhakar K Jadhav, John R Wetterau
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0292091 (2024)
Many of the pathological consequences of chronic kidney disease can be attributed to an elevation in serum phosphate levels. Current therapies focused on decreasing intestinal phosphate absorption to treat hyperphosphatemia are inadequate. The most e
Externí odkaz:
https://doaj.org/article/d4d6b1aa436147f6aee23698faf6982e
Autor:
Kostas Gavardinas, John G. Luz, Nathan A. Calvert, Vaught Grant Matthews, Pablo Garcia Losada, Heather A Bullock, Ashraf Saeed, Donald P. Matthews, Yong Wang, Nita J. Patel, Venkatesh Krishnan, Judith W. Henck, Jonathan Edward Green, Sweetana Stephanie Ann, Prabhakar Kondaji Jadhav
Publikováno v:
Journal of Medicinal Chemistry. 59:750-755
A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fb49ad5057da8c107176f52e98ce6e
https://doi.org/10.1021/acs.jmedchem.5b01168
https://doi.org/10.1021/acs.jmedchem.5b01168
Autor:
Bruce W. Shaw, Yuke Zhang, Kenneth C. Cassidy, Robert M. Christie, Prabhakar Kondaji Jadhav, Jim D. Durbin, Gary G. Deng, Matthew Allen Schiffler, Kostas Gavardinas, Richard A. Brier, Keyun Qing, Donald P. Matthews, Michael A. Staszak, William F. Matter, Yong Wang, Kim Euibong Jemes, D. Scott Coffey
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1138-1142
Cathepsin S (Cat S) plays an important role in many pathological conditions, including abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. To date, several classes of Cat S inhibitors have been reported, many of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6393a9fc5f96e20e55b6bf40e534a7b3
https://doi.org/10.1021/ml500283g
https://doi.org/10.1021/ml500283g
Publikováno v:
The Journal of Organic Chemistry. 65:1407-1413
Rates and products of the reactions of trans- and cis-beta-methyl-4-methoxystyrene oxides (1 and 2) (anethole oxides) and beta,beta-dimethyl-4-methoxystyrene oxide (3) in water solutions in the pH range 4-12 have been determined. In the pH range ca.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc86601d7b537216c9954be8bf612d14
https://doi.org/10.1021/jo991521b
https://doi.org/10.1021/jo991521b
Publikováno v:
Journal of Chemical Education. 77:79
Epoxides, or oxiranes, are among the most versatile intermediates in organic synthesis. Yet very few examples of laboratory experiments involving reactions of epoxides are to be found in lab texts. We have developed a discovery-oriented laboratory ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02514416e8d58027b45b62d74d9f6ea3
https://doi.org/10.1021/ed077p79
https://doi.org/10.1021/ed077p79
Publikováno v:
Journal of Chemical Education. 76:535
Nitration is one of the most fundamental reactions in organic chemistry. However, the majority of the nitration experiments found in the standard lab textbooks are of the "cookbook" variety and convey none of the excitement associated with discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d93bb0b94f0d143ecb170aeef809275
https://doi.org/10.1021/ed076p535
https://doi.org/10.1021/ed076p535