Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kostas C. Nikolaou"'
Autor:
Ourania Galanopoulou, Evangelia C. Tachmatzidi, Elena Deligianni, Dimitris Botskaris, Kostas C. Nikolaou, Sofia Gargani, Yannis Dalezios, Georges Chalepakis, Iannis Talianidis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Setd8 regulates transcription elongation, mitotic DNA condensation, DNA damage response and replication licensing. Here we show that, in mitogen-stimulated liver-specific Setd8-KO mice, most of the hepatocytes are eliminated by necrosis but
Externí odkaz:
https://doaj.org/article/7a63db086b584fafb014bb779aded084
Autor:
Kostas C. Nikolaou, Svenja Godbersen, Muthiah Manoharan, Stefan Wieland, Markus H. Heim, Markus Stoffel
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Nonalcoholic steatohepatitis (NASH) is a leading cause for chronic liver diseases. Current therapeutic options are limited due to an incomplete mechanistic understanding of how steatosis transitions to NASH. Here we show that the TRIM21 E3 ubiquitin
Externí odkaz:
https://doaj.org/article/f988f56d53784cf294e71475462e5233
Autor:
Kostas C. Nikolaou, Panagiotis Moulos, Vangelis Harokopos, George Chalepakis, Iannis Talianidis
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 909-922 (2017)
H4K20 monomethylation maintains genome integrity by regulating proper mitotic condensation, DNA damage response, and replication licensing. Here, we show that, in non-dividing hepatic cells, H4K20Me1 is specifically enriched in active gene bodies and
Externí odkaz:
https://doaj.org/article/2b0629ecbcb9486d83f91d4c90636761
Autor:
Kostas C. Nikolaou, Hasan Vatandaslar, Cindy Meyer, Marc W. Schmid, Thomas Tuschl, Markus Stoffel
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 283-300.e8 (2019)
Summary: The regulation of hepatic gene expression has been extensively studied at the transcriptional level; however, the control of metabolism through posttranscriptional gene regulation by RNA-binding proteins in physiological and disease states i
Externí odkaz:
https://doaj.org/article/1cd0664ae89e4613a2b2d17e371781f6
Autor:
Maximilianos Elkouris, Haroula Kontaki, Athanasios Stavropoulos, Anastasia Antonoglou, Kostas C. Nikolaou, Martina Samiotaki, Eszter Szantai, Dimitra Saviolaki, Peter J. Brown, Paschalis Sideras, George Panayotou, Iannis Talianidis
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2733-2744 (2016)
TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic activity o
Externí odkaz:
https://doaj.org/article/d6d19049a7334b35a8b9cfd507b446c8
Autor:
Peter Brown, Kostas C. Nikolaou, Maximilianos Elkouris, Anastasia Antonoglou, George Panayotou, Martina Samiotaki, Haroula Kontaki, Paschalis Sideras, Iannis Talianidis, Eszter Szantai, Athanasios Stavropoulos, Dimitra Saviolaki
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2733-2744 (2016)
Cell Reports
Cell Reports
Summary TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0635c40693fedf865e45fe9d02bfa419
http://www.sciencedirect.com/science/article/pii/S2211124716306490
http://www.sciencedirect.com/science/article/pii/S2211124716306490
Autor:
Panagiotis Moulos, Danny Reinberg, Pantelis Hatzis, Hisanobu Oda, Iannis Talianidis, George Chalepakis, Kostas C. Nikolaou
Publikováno v:
The EMBO Journal. 34:430-447
PR-SET7-mediated histone 4 lysine 20 methylation has been implicated in mitotic condensation, DNA damage response and replication licensing. Here, we show that PR-SET7 function in the liver is pivotal for maintaining genome integrity. Hepatocyte-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4569faf9737fe347d54e402815a5d71c
https://doi.org/10.15252/embj.201489279
https://doi.org/10.15252/embj.201489279
Publikováno v:
Clinical Cancer Research
Inflammatory signals from the surrounding microenvironment play important roles in tumor promotion. Key inflammatory mediators and pathways that induce and sustain tumorigenesis have recently been identified in many different cancers. Hepatocellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cd59e8ab1ca04fbc364f43ea183dc7
https://doi.org/10.1158/1078-0432.ccr-12-1961
https://doi.org/10.1158/1078-0432.ccr-12-1961
Autor:
Kostas C. Nikolaou, Iannis Talianidis, George Mosialos, George Kollias, Christina Eftychi, Ageliki Tsagaratou
Publikováno v:
Cancer Cell; Vol 21
Cancer Cell
Cancer Cell
SummaryThe tumor suppressor cylindromatosis (CYLD) inhibits the NFκB and mitogen-activated protein kinase (MAPK) activation pathways by deubiquitinating upstream regulatory factors. Here we show that liver-specific disruption of CYLD triggers hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec923f358d14b4d6a30ec1c45440130c
Publikováno v:
Oncogene
Altered expression or activity of histone lysine methylases and demethylases in cancer lead to aberrant chromatin modification patterns, which contribute to uncontrolled cell proliferation via cancer-specific deregulation of gene expression programs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb5d0184b09d478459e5695e6eec2a6
https://pubmed.ncbi.nlm.nih.gov/23503463
https://pubmed.ncbi.nlm.nih.gov/23503463