Algorithmic assessment of cellular senescence in experimental and clinical specimens

Autor: Jaskaren Kohli, Marco Demaria, Nathan Basisty, Simone Brandenburg, Birgit Schilling, Judith Campisi, Boshi Wang, Marta Varela-Eirin, Vassilis G. Gorgoulis, Kostas Evangelou

Publikováno v: Nat Protoc

The development of genetic tools allowed for the validation of the pro-aging and pro-disease functions of senescent cells in vivo. These discoveries prompted the development of senotherapies-pharmaceutical interventions aimed at interfering with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fd45a6a96a3d6de23ae855dbbe599a
https://doi.org/10.1038/s41596-021-00505-5

Hepatocyte autotaxin expression promotes liver fibrosis and cancer

Autor: George N. Dalekos, Urania Georgopoulou, Anargyros N. Moulas, Markella Zannikou, Aggeliki Katsifa, Vassilis Aidinis, Vassilis G. Gorgoulis, Kostas Evangelou, Ioanna Ninou, Pelagia Foka, Vaggelis Harokopos, Eleanna Kaffe, Alexios Dimitriadis, Nikos Xylourgidis

Publikováno v: Hepatology (Baltimore, Md.). 65(4)

Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth-factor–like lysophospholipid. Increased ATX expression has been detected in various chronic inflammatory disorders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76f131e5981b4dd8ff55cff943446fb
https://pubmed.ncbi.nlm.nih.gov/27981605

Oral non-Hodgkin’s lymphoma in a patient with rheumatoid arthritis treated with etanercept and methotrexate

Autor: Kostas Evangelou, Marina D. Achtari, Christos Kittas, Eleni A Georgakopoulou

Publikováno v: Georgakopoulou, Eleni A. ; Achtari, Marina D. ; Evangelou, Kostas ; Kittas, Christos. Oral non-Hodgkin’s lymphoma in a patient with rheumatoid arthritis treated with etanercept and methotrexate. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 1: 180-182
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Journal of Clinical and Experimental Dentistry

Oral non-Hodgkin’s lymphomas (O-NHLs) are a rare group of diverse lymphoid tissue malignancies and represent less than 5% of the oral cavity malignancies and 2% of all extra-nodal NHLs. Oral-NHLs affect the Waldeyer’s-ring, the salivary glands, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3a3a4baba0daedfc9b3424addf3d45
http://hdl.handle.net/10550/42389

The tumor suppressor gene ARF as a sensor of oxidative stress

Autor: Kostas Evangelou, Ioannis S. Pateras, Michalis Liontos, Vassilis G. Gorgoulis

Publikováno v: Current molecular medicine. 12(6)

Oxidative stress as a result of either exogenous stimuli or cellular metabolism affects several cellular processes such as proliferation, apoptosis, cell death and senescence. Consequently, it is implicated in the pathogenesis of various human diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de46ad013e2ff87e89366ef661c7abe9
https://pubmed.ncbi.nlm.nih.gov/22292438

Effects of prolonged warm and cold ischemia in a solitary kidney animal model after partial nephrectomy: an ultrastructural investigation

Autor: Theodoros Troupis, Constantinos A. Constantinides, Aspasia Kyroudi-Voulgari, Vassilis G. Gorgoulis, Kostas Evangelou, Stavros I. Tyritzis, Kitty Pavlakis, Michael Zachariades

Publikováno v: Ultrastructural pathology. 35(2)

aBstra Ct Ischemia–reperfusion injury can be detrimental to the solitary kidney, especially when it is accompanied by ablation. To the authors’ knowledge, the effects of partial nephrectomy with prolonged application of ischemia have never been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcef2c35d20539bd8500583e54a6111
https://pubmed.ncbi.nlm.nih.gov/21299345