Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kostas, Dimas"'
Autor:
Andrew Tsotinis, Stavroula Georgakopoulou, Stefanos Riganas, Jean-François Mirjolet, Maria Theodoropoulou, Margarita Prassa, Vassilios I. Moutsos, Andreas Eleutheriades, Guillaume Serin, Alexandre Vamvakides, Humaira Khan, Angeliki Zaniou, Athanasios Mantelas, Ioannis Papanastasiou, George B. Foscolos, Kostas Dimas, Stavroula Pondiki, Vassilios N. Kourafalos
Publikováno v:
Journal of Medicinal Chemistry. 55:10241-10261
The synthesis of the adamantane phenylalkylamines 2a-d, 3a-c, and 4a-e is described. These compounds exhibited significant antiproliferative activity, in vitro, against eight cancer cell lines tested. The σ(1), σ(2), and sodium channel binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7d92d915313f76ad8e08acaf62cf05
https://doi.org/10.1021/jm3013008
https://doi.org/10.1021/jm3013008
Autor:
Andrew Tsotinis, Margarita Prassa, Guillaume Serin, Ioannis Papanastasiou, Humaira Khan, Stavroula Georgakopoulou, Vassilios I. Moutsos, Jean-Jacques Bourguignon, Jean-François Mirjolet, Vassilios N. Kourafalos, Angeliki Zaniou, Alexandre Vamvakides, Stavroula Pondiki, Stefanos Riganas, Andreas Eleutheriades, George B. Foscolos, Kostas Dimas, Maria Theodoropoulou
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:3323-3331
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f08a918951df6498e0fc5e76bc3786e4
https://doi.org/10.1016/j.bmc.2012.03.038
https://doi.org/10.1016/j.bmc.2012.03.038
Autor:
Sophia Hatziantoniou, P. Pantazis, Magdalini Papadaki, Costas Demetzos, Konstantinos Alevizopoulos, Kostas Dimas, C. Tsimplouli
Publikováno v:
Biomedicine & Pharmacotherapy. 60:127-133
Sclareol is a labdane-type diterpene that has demonstrated a significant cytotoxic activity against human leukemic cell lines. Here, we report the effect of sclareol against the human breast cancer cell lines MN1 and MDD2 derived from the parental ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8824099418e5827179be1374c10e14ce
https://doi.org/10.1016/j.biopha.2006.01.003
https://doi.org/10.1016/j.biopha.2006.01.003
Publikováno v:
International Journal of Pharmaceutics. 302:29-38
Liposomes composed of HePC:EPC:SA 10:10:0.1 (molar ratio) (1) and EPC:SA 10:0.1 (molar ratio) (2) were prepared and were used for incorporating the doxorubicin-PAMAM complex (3:1 molar ratio) (3). The doxorubicin-PAMAM complex was attached to liposom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a05d367a96fd510d3b6aef74380a7b
https://doi.org/10.1016/j.ijpharm.2005.05.039
https://doi.org/10.1016/j.ijpharm.2005.05.039
Publikováno v:
Planta Medica. 68:649-652
Sesquiterpene lactones isolated from the aerial parts of various species of the genus Centaurea were examined for their in vitro cytotoxic/cytostatic activity against five human cell lines (i. e., DLD1, SF268, MCF7, H460 and OVCAR3). Compounds 1 - 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697b0cc69e05fce352210b5bee42f314
https://doi.org/10.1055/s-2002-32893
https://doi.org/10.1055/s-2002-32893
Autor:
Marios Marselos, Costas Demetzos, Sofia Mitaku, Dimitrios Kokkinopoulos, Theodoros Tzavaras, Kostas Dimas
Publikováno v:
Scopus-Elsevier
Two kaempferol coumaroyl glycosides (i.e. platanoside and tiliroside) isolated from the methanolic extract of Platanus orientalis L. buds, were examined for their in vitro cytotoxic activity against a panel of human leukaemic cell lines. Platanoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0586d92439dcb836690cd0f611f9d87e
https://doi.org/10.1006/phrs.1999.0562
https://doi.org/10.1006/phrs.1999.0562
Autor:
Marios Marselos, Costas Demetzos, Basilios Vaos, Kostas Dimas, Mixalis Malamas, Theodoros Tzavaras, Dimitrios Kokkinopoulos
Publikováno v:
Leukemia Research. 23:217-234
Sclareol, a labdane-type diterpene, was tested for cytotoxic effect against a panel of established human leukemic cell lines. The compound showed an IC50 lower than 20 microg/ml in most cell lines tested, while it was higher for resting peripheral bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51134a6fab4deed299c7497cf7331774
https://doi.org/10.1016/s0145-2126(98)00134-9
https://doi.org/10.1016/s0145-2126(98)00134-9
Autor:
Maria Hatziapostolou, Margarita Lamprou, Panagiota Ravazoula, Kostas Dimas, Evangelia Papadimitriou, Sotiria Tsirmoula
Publikováno v:
Cancer Sci
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse functions related to tumor growth, angiogenesis, and metastasis. Pleiotrophin seems to have a significant role in prostate cancer cell growth and to mediate the stimulatory actions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11225c7dc27e37ddd9c216b991754b56
https://pubmed.ncbi.nlm.nih.gov/22783964
https://pubmed.ncbi.nlm.nih.gov/22783964
Autor:
Stefanos, Riganas, Ioannis, Papanastasiou, George B, Foscolos, Andrew, Tsotinis, Jean-Jacques, Bourguignon, Guillaume, Serin, Jean-François, Mirjolet, Kostas, Dimas, Vassilios N, Kourafalos, Andreas, Eleutheriades, Vassilios I, Moutsos, Humaira, Khan, Stavroula, Georgakopoulou, Angeliki, Zaniou, Margarita, Prassa, Maria, Theodoropoulou, Stavroula, Pondiki, Alexandre, Vamvakides
Publikováno v:
Bioorganicmedicinal chemistry. 20(10)
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ(1), σ(2)-receptors and sodium channels binding affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d447cb46ae5744572bcd716ee4626168
https://pubmed.ncbi.nlm.nih.gov/22512908
https://pubmed.ncbi.nlm.nih.gov/22512908
Autor:
Andreas Eleutheriades, Vassilios N. Kourafalos, Athanasios Mantelas, Ioannis Papanastasiou, Alexandre Vamvakides, Stavroula Pondiki, Stavroula Georgakopoulou, Stefanos Riganas, Vassilios I. Moutsos, Kostas Dimas, George B. Foscolos, Maria Theodoropoulou, Prassa Margarita, Angeliki Zaniou, Andrew Tsotinis, Humaira Khan
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 8(4)
The synthesis of 4-(1-adamantyl)-4,4-diarylbutylamines 1, 5-(1-adamantyl)-5,5-diarylpentylamines 2 and 6-(1-adamantyl)-6,6-diarylhexylamines 3 is described and the σ1, σ2-receptors and sodium channels binding affinity of compounds 1 were investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5464ba0d4af1b4e2b36106d595064449
https://pubmed.ncbi.nlm.nih.gov/22530894
https://pubmed.ncbi.nlm.nih.gov/22530894