IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes

Autor: Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte, Antoni Torres, Michael Tamm, Daiana Stolz

Publikováno v: BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-9 (2018)

Abstract Background Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? Methods Five hundred twenty eight patients were recruited in a

Externí odkaz: https://doaj.org/article/9ea0eacc819f42c28797de1a0b3a530c

Predicting the need for mechanical ventilation and mortality in hospitalized COVID-19 patients who received heparin

Autor: Vasileios C. Pezoulas, Angelos Liontos, Eugenia Mylona, Costas Papaloukas, Orestis Milionis, Dimitrios Biros, Chris Kyriakopoulos, Kostantinos Kostikas, Haralampos Milionis, Dimitrios I. Fotiadis

Publikováno v: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2022

Although several studies have utilized AI (artificial intelligence)-based solutions to enhance the decision making for mechanical ventilation, as well as, for mortality in COVID-19, the extraction of explainable predictors regarding heparin's effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684447a90ce51616e96baf16a72e58de
https://pubmed.ncbi.nlm.nih.gov/36086001

The role of non-invasive modalities for assessing inflammation in patients with non-cystic fibrosis bronchiectasis

Autor: Loukas Thanos, Katerina Dimakou, Stelios Loukides, Andriana I. Papaioannou, Nickolaos G. Koulouris, Stamatoula Tsikrika, Kostantinos Kostikas, Petros Bakakos, Spyros Papiris, Georgios Hillas

Publikováno v: Cytokine. 99:281-286

Introduction Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59048ee51a3982ae352518038eb24588
https://doi.org/10.1016/j.cyto.2017.08.005

At the root:Defining and halting progression of early chronic obstructive pulmonary disease

Autor: Renat Shaykhiev, MeiLan K. Han, R. Graham Barr, Stephen I. Rennard, Prescott G. Woodruff, Jørgen Vestbo, Eric A. Hoffman, Christine M. Freeman, Leopoldo N. Segal, Mehmet Kesimer, Jeffrey L. Curtis, Robert Paine, Kostantinos Kostikas, Peter M.A. Calverley, Christopher S. Stevenson, Shahin Rafii, Lars Groenke, Stephanie A. Christenson, Fernando J. Martinez, Malin Fagerås, Jadwiga A. Wedzicha, Ruth Tal-Singer, Bartolome R. Celli, James Allinson, Richard C. Boucher, Ronald G. Crystal

Publikováno v: Martinez, F J, Han, M K, Allinson, J P, Graham Barr, R, Boucher, R C, Calverley, P M A, Celli, B R, Christenson, S A, Crystal, R G, Fageras, M, Freeman, C M, Groenke, L, Hoffman, E A, Kesimer, M, Kostikas, K, Paine, R, Rafii, S, Rennard, S I, Segal, L N, Shaykhiev, R, Stevenson, C, Tal-Singer, R, Vestbo, J, Woodruff, G P, Curtis, J L & Wedzicha, J A 2018, ' At the root : Defining and halting progression of early chronic obstructive pulmonary disease ', American Journal of Respiratory and Critical Care Medicine, vol. 197, no. 12, pp. 1540-1551 . https://doi.org/10.1164/rccm.201710-2028PP
Martinez, F J, Han, M K, Allinson, J P, Graham Barr, R, Boucher, R C, Calverley, P M A, Celli, B R, Christenson, S, Crystal, R G, Fagerås, M, Freeman, C, Gröenke, L, Hoffman, E A, Kesimer, M, Kostikas, K, Paine III, R, Rafii, S, Rennard, S I, Segal, L N, Shaykhiev, R, Stevenson, C, Tal-Singer, R, Vestbo, J, Woodruff, P G, Curtis, J L & Wedzicha, J A 2018, ' At the root: defining and halting progression of early chronic obstructive pulmonary disease ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201710-2028PP

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder with varying presentations and progression, but limited disease-modifying therapies. Trajectories of lung function decline in COPD differ significantly between individuals, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a8eb6c166d34cd2bf24055a11bdb33
https://findresearcher.sdu.dk:8443/ws/files/151947884/At_the_root.pdf

IFNL3 polymorphisms are associated with COPD severity and outcomes

Autor: Daiana Stolz, Desiree M. Schumann, Adrian Egli, Jyotshna Mandal, Michael Roth, Brad Thomas, Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Gernot G.U. Rohde, Renaud Louis, Joachim Aerts, Tobias Welte, Antoni Torres, Michael Tamm

Publikováno v: Clinical Problems COPD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92dcc9a13bdb3e56b04a158ceeb6559a
https://doi.org/10.1183/1393003.congress-2017.oa506