Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kostantin Kiianitsa"'
Autor:
Olena Korvatska, Kostantin Kiianitsa, Alexander Ratushny, Mark Matsushita, Neal Beeman, Wei-Ming Chien, Jun-Ichi Satoh, Michael O. Dorschner, C. Dirk Keene, Theo K. Bammler, Thomas D. Bird, Wendy H. Raskind
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The R47H variant in the microglial triggering receptor expressed on myeloid cell 2 (TREM2) receptor is a strong risk factor for Alzheimer’s disease (AD). To characterize processes affected by R47H, we performed an integrative network analysis of ge
Externí odkaz:
https://doaj.org/article/473307c7b17f4f2c97dff1c8062620f1
Autor:
William C. Edelman, Kostantin Kiianitsa, Tuhin Virmani, Refugio A. Martinez, Jessica E. Young, C. Dirk Keene, Thomas D. Bird, Wendy H. Raskind, Olena Korvatska
Publikováno v:
Parkinsonismrelated disorders. 101
Mutations that alter splicing of X-linked ATP6AP2 cause a spectrum of neurodevelopmental and neurodegenerative pathologies including parkinsonism in affected males. All previously reported splicing mutations increase the level of a minor isoform with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a4be1e2129a969a376d86671a1f121
https://pubmed.ncbi.nlm.nih.gov/35779466
https://pubmed.ncbi.nlm.nih.gov/35779466
Publikováno v:
Journal of Biological Chemistry. 299:103405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb96e884e7fde31db99973c484406aa
https://doi.org/10.1016/j.jbc.2023.103405
https://doi.org/10.1016/j.jbc.2023.103405
Publikováno v:
Curr Protoc
Topoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single-stranded cuts in DNA, and type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0316781fb9b4042b6fa6751691f43624
https://doi.org/10.1002/cpz1.250
https://doi.org/10.1002/cpz1.250
Autor:
Wendy H. Raskind, Mark Matsushita, Irina Kurtz, Neal Beeman, Kostantin Kiianitsa, Olena Korvatska, Wei-Ming Chien
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoglobulin-like receptor expressed by certain myeloid cells, such as macrophages, dendritic cells, osteoclasts, and microglia. In the brain, TREM2 plays an important role in the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa046335320b32c524508260aba4983
https://doi.org/10.1101/2020.11.30.404897
https://doi.org/10.1101/2020.11.30.404897
Publikováno v:
DNA Repair (Amst)
The nucleoside analog 5-aza-2'-deoxycytidine (5-aza-dC) is used to treat some hematopoietic malignancies. The mechanism of cell killing depends upon DNMT1, but is otherwise not clearly defined. Here we show that PARP1 forms covalent DNA adducts in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cf17bfeea0eec478041d1e36c21417
https://pubmed.ncbi.nlm.nih.gov/33039802
https://pubmed.ncbi.nlm.nih.gov/33039802
Publikováno v:
Anal Biochem
Topoisomerases are proven drug targets, but antibiotics that poison bacterial Topoisomerase 1 (Top1) have yet to be discovered. We have developed a rapid and direct assay for quantification of Top1-DNA adducts that is suitable for high throughput ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af1f6b4e6acae9d07b556b9356f1a23
https://doi.org/10.1101/2020.03.09.984153
https://doi.org/10.1101/2020.03.09.984153
Autor:
Nancy Maizels, Kostantin Kiianitsa
Publikováno v:
DNA Repair (Amst)
Proteins form adducts with nucleic acids in a variety of contexts, and these adducts may be cytotoxic if not repaired. Here we apply a proteomic approach to identification of proteins adducted to DNA or RNA in normally proliferating cells. This appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747ba4103f45abac89b0c0e1f9480012
https://europepmc.org/articles/PMC7197468/
https://europepmc.org/articles/PMC7197468/
Autor:
Nancy Maizels, Kostantin Kiianitsa, Luther Davis, Yilun Liu, Theo A. Knijnenburg, Kevin J Khoo, Henry C Olson
Publikováno v:
Nucleic Acids Research
RECQ5 (RECQL5) is one of several human helicases that dissociates RAD51–DNA filaments. The gene that encodes RECQ5 is frequently amplified in human tumors, but it is not known whether amplification correlates with increased gene expression, or how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7706adc3f2e8e9fa377335a167fc02c3
https://doi.org/10.1093/nar/gky727
https://doi.org/10.1093/nar/gky727
Autor:
Nancy Maizels, Kostantin Kiianitsa
The nucleoside analog 5-aza-2’-deoxycytidine (5-aza-dC) is used to treat some hematopoietic malignancies. The mechanism of cell killing depends upon DNMT1, but is otherwise not clearly defined. Here we show that PARP1 forms covalent DNA adducts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bd2442c84d9886ce1ed7ebe22fd66e
https://doi.org/10.1101/538645
https://doi.org/10.1101/538645