Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kostandin V. Pajcini"'
Autor:
Kilian Sottoriva, Na Yoon Paik, Zachary White, Thilinie Bandara, Lijian Shao, Teruyuki Sano, Kostandin V. Pajcini
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Long-term impairment in T cell–mediated adaptive immunity is a major clinical obstacle following treatment of blood disorders with hematopoietic stem cell transplantation. Although T cell development in the thymus has been extensively characterized
Externí odkaz:
https://doaj.org/article/e14c47cc97674980b7c99037dc1b8d44
Autor:
Kilian Sottoriva, Kostandin V. Pajcini
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Lifelong mammalian hematopoiesis requires continuous generation of mature blood cells that originate from Hematopoietic Stem and Progenitor Cells (HSPCs) situated in the post-natal Bone Marrow (BM). The BM microenvironment is inherently complex and e
Externí odkaz:
https://doaj.org/article/74eac2c6ffe44855863a62c32943dffb
Autor:
Lijian Shao, Kilian Sottoriva, Karol Palasiewicz, Jizhou Zhang, James Hyun, Sweta S. Soni, Na Yoon Paik, Xiaopei Gao, Henar Cuervo, Asrar B. Malik, Jalees Rehman, Daniel Lucas, Kostandin V. Pajcini
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhibiting hypo
Externí odkaz:
https://doaj.org/article/c7d358a8235d4d9c9812091cb315a357
Autor:
Kit Man Tsang, James S. Hyun, Kwong Tai Cheng, Micaela Vargas, Dolly Mehta, Masuko Ushio-Fukai, Li Zou, Kostandin V. Pajcini, Jalees Rehman, Asrar B. Malik
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 796-806 (2017)
The generation of functional arterial endothelial cells (aECs) from embryonic stem cells (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing isch
Externí odkaz:
https://doaj.org/article/e143983cc20a4867bd614c0172778c45
Autor:
Johanna Finn, Kilian Sottoriva, Kostandin V. Pajcini, Jan K. Kitajewski, Chang Chen, Wei Zhang, Asrar B. Malik, Yuru Liu
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 2942-2954.e5 (2019)
Summary: Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, in
Externí odkaz:
https://doaj.org/article/01f351cd90214d9b9d6b15c8d7353b49
Autor:
Timothy Sargis, Seock-Won Youn, Krishna Thakkar, L. A. Naiche, Na Yoon Paik, Kostandin V. Pajcini, Jan K. Kitajewski
Publikováno v:
Angiogenesis. 26:249-263
The Notch signaling pathway is an important therapeutic target for the treatment of inflammatory diseases and cancer. We previously created ligand-specific inhibitors of Notch signaling comprised of Fc fusions to specific EGF-like repeats of the Notc
Autor:
Lijian Shao, Na Yoon Paik, Mark A. Sanborn, Thilinie Bandara, Anjali Vijaykumar, Kilian Sottoriva, Jalees Rehman, Cesar Nombela-Arrieta, Kostandin V. Pajcini
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs) in the embryo and their development in the fetal liver niche. However, how Notch signaling is activated and which fetal liver cell type provides the ligand f
Autor:
Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R. Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E. Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V. Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L. Oliveira, Marco Constante, Manuela M. Santos, Carlos R. Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho, Soroush Tahmasebi
Publikováno v:
Proceedings of the National Academy of Sciences. 119
GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that controls messenger RNA translation in response to amino acid availability and ribosome stalling. Here, we show that GCN2 controls erythrocyte clearance and iron recyc
Autor:
Hal E. Broxmeyer, Brian J. Cox, Anthony L. Sinn, Adedamola Elujoba-Bridenstine, Laura M. Sanchez, Lijian Shao, Scott Cooper, Emily Sims, Karen E. Pollok, Barbara J. Bailey, Kostandin V. Pajcini, Katherine E. Zink, Owen J. Tamplin
Publikováno v:
Blood. 137:775-787
Hematopoietic and nervous systems are linked via innervation of bone marrow (BM) niche cells. Hematopoietic stem/progenitor cells (HSPCs) express neurotransmitter receptors, such as the γ-aminobutyric acid (GABA) type B receptor subunit 1 (GABBR1),
Autor:
Asrar B. Malik, Jalees Rehman, Kostandin V. Pajcini, James Hyun, Jennifer E. Klomp, Jeff Klomp
Publikováno v:
J Biol Chem
Endothelial cells (ECs) lining the vasculature of vertebrates respond to low oxygen (hypoxia) by maintaining vascular homeostasis and initiating adaptive growth of new vasculature through angiogenesis. Previous studies have uncovered the molecular un