Design and synthesis of novel amino-substituted xanthenones and benzo[b]xanthenones: Evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D x 5 cells

Autor: Kostakis, IK Pouli, N Marakos, P Skaltsounis, AL and Pratsinis, H Kletsas, D

A number of new xanthenone and benzo[b]xanthenone amino derivatives and their pyrazole-fused Counterparts have been designed and synthesized possessing structural analogy to the potent anticancer agent 9-methoxypyrazoloacridine. The synthesis of the

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https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3099334

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A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux.

Autor: Zhang G; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Wang M; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Gao Y; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Komianou AC; Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece., Georgiou EA; Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece., Wang Y; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Zheng Y; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Liu J; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.; School of Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, China., Kostakis IK; Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece., Zhao L; Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Cardiometabolic Innovation Center, Ministry of Education, Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2024 Sep; Vol. 41 (7-9), pp. 430-461. Date of Electronic Publication: 2024 Mar 27.

Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3 H )-Ones with Antiproliferative Activities.

Autor: Karelou M; Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece., Kampasis D; Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece., Kalampaliki AD; Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece., Persoons L; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Herestraat 49, P.O. Box 1043, 3000 Leuven, Belgium., Krämer A; Institute for Pharmaceutical Chemistry, Department of Biochemistry, Chemistry and Pharmacy, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt, Germany., Schols D; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Herestraat 49, P.O. Box 1043, 3000 Leuven, Belgium., Knapp S; Institute for Pharmaceutical Chemistry, Department of Biochemistry, Chemistry and Pharmacy, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438 Frankfurt, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt, Germany., De Jonghe S; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Herestraat 49, P.O. Box 1043, 3000 Leuven, Belgium., Kostakis IK; Department of Pharmacy, Division of Pharmaceutical Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, Greece.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 02; Vol. 28 (23). Date of Electronic Publication: 2023 Dec 02.