PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention

Autor: Kostadinova, Atanaska I., Middelburg, Jim, Ciulla, Michele, Garssen, Johan, Hennink, Wim E., Knippels, Leon M.J., van Nostrum, Cornelus F., Willemsen, Linette E.M.

Publikováno v: In European Journal of Pharmacology 5 January 2018 818:211-220

Combined Exposure of Activated Intestinal Epithelial Cells to Nondigestible Oligosaccharides and CpG-ODN Suppresses Th2-Associated CCL22 Release While Enhancing Galectin-9, TGFβ, and Th1 Polarization.

Autor: Overbeek, Saskia A.¹, Kostadinova, Atanaska I.^1,2, Boks, Martine A.³, Hayen, Simone M.^1,4, de Jager, Wilco⁵, van't land, Belinda^2,6, Knippels, Leon M.², Garssen, Johan^1,2, Willemsen, Linette E. M.¹

Publikováno v: Mediators of Inflammation. 7/25/2019, p1-14. 14p.

Exposure of intestinal epithelial cells to 2′-fucosyllactose and cpg enhances galectin release and instructs dendritic cells to drive th1 and regulatory-type immune development

Autor: Ayechu-Muruzabal, Veronica, Overbeek, Saskia A., Kostadinova, Atanaska I., Stahl, Bernd, Garssen, Johan, Van’T Land, Belinda, Willemsen, Linette E.M., Afd Pharmacology, Afd Chemical Biology and Drug Discovery, Pharmacology, Chemical Biology and Drug Discovery

Publikováno v: Biomolecules, 10(5). Multidisciplinary Digital Publishing Institute (MDPI)
Biomolecules
Volume 10
Issue 5
Biomolecules, Vol 10, Iss 784, p 784 (2020)

Intestinal epithelial cells (IEC) release immunomodulatory galectins upon exposure to CpG DNA (mimicking bacterial triggers) and short-chain galacto- and long-chain fructo-oligosaccharides (GF). This study aims to investigate the immunomodulatory pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb7cfa606c34c6e929a25c015ded33c
https://dspace.library.uu.nl/handle/1874/408693

Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation

Autor: de Kivit, Sander, Kostadinova, Atanaska I, Kerperien, JoAnn, Morgan, Mary E, Muruzabal, Veronica Ayechu, Hofman, Gerard A, Knippels, Leon M J, Kraneveld, Aletta D, Garssen, Johan, Willemsen, Linette E M

Dietary intervention with short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V (Bb) (GF/Bb) suppresses food allergic symptoms in mice, potentially via intestinal epithelial cell (IEC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______101::1f0b6494c9cfe2caaae58229f1fa3760
https://dspace.library.uu.nl/handle/1874/358512

A Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates Partial Non-Responsiveness to Whey Protein in Mice Orally Exposed to β-Lactoglobulin-Derived Peptides

Autor: Kostadinova, Atanaska I, Meulenbroek, Laura A P M, van Esch, Betty C A M, Hofman, Gerard A, Garssen, Johan, Willemsen, Linette E M, Knippels, Léon M J, Afd Pharmacology, Sub Immunopharmacology, Pharmacology

Publikováno v: Frontiers in Immunology, 7. Frontiers Media S.A.
Frontiers in Immunology

Oral tolerance is a promising approach for allergy prevention in early life, but it strongly depends on allergen exposure and proper immune environment. Small tolerance-inducing peptides and dietary immunomodulatory components may comprise an attract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ed62014cb3454c4efbcd47c71a15a7
https://doi.org/10.3389/fimmu.2016.00673