Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Autor: Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Carpintero M; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Diego JE; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Barberis M; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Garcia-Cerrada S; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Soriano JF; Discovery Chemistry Synthesis Group, Centro de Investigación Lilly S.A. Avda. de la Industria , 30 Alcobendas, Madrid 28108, Spain., Antonysamy S; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Atwell S; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., MacEwan I; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Condon B; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Sougias C; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Wang J; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Zhang A; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Conners K; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Groshong C; Structural Biology, Lilly Biotechnology Center, Eli Lilly and Company , San Diego, California 92121, United States., Wasserman SR; Structural Biology, Eli Lilly and Company, Advanced Photon Source, Argonne National Laboratory, Building 438A, 9700 South Cass Avenue, Argonne, Illinois 60439, United States., Koss JW; Structural Biology, Eli Lilly and Company, Advanced Photon Source, Argonne National Laboratory, Building 438A, 9700 South Cass Avenue, Argonne, Illinois 60439, United States., Witkin JM, Li X, Overshiner C, Wafford KA; Neuroscience Research, Eli Lilly and Company , Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, U.K. GU20 6PH., Seidel W; Neuroscience Research, Eli Lilly and Company , Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, U.K. GU20 6PH., Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 22; Vol. 59 (24), pp. 10974-10993. Date of Electronic Publication: 2016 Dec 06.