Discovery of novel, orally active dual NK 1/NK 2 antagonists

Autor: Bernstein, Peter R., Aharony, David, Albert, Jeffrey S., Andisik, Donald, Barthlow, Herbert G., Bialecki, Russell, Davenport, Timothy, Dedinas, Robert F., Dembofsky, Bruce T., Koether, Gerard, Kosmider, Benedict J., Kirkland, Karin, Ohnmacht, Cyrus J., Potts, William, Rumsey, William L., Shen, Lihong, Shenvi, Ashok, Sherwood, Scott, Stollman, David, Russell, Keith

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2001 11(20):2769-2773

Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.

Autor: Albert JS; CNS Discovery Research, AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, P.O. Box 15437, Wilmington, Delaware 19850-5437, USA. jeffrey.albert@astrazeneca.com, Aharony D, Andisik D, Barthlow H, Bernstein PR, Bialecki RA, Dedinas R, Dembofsky BT, Hill D, Kirkland K, Koether GM, Kosmider BJ, Ohnmacht C, Palmer W, Potts W, Rumsey W, Shen L, Shenvi A, Sherwood S, Warwick PJ, Russell K

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Aug 29; Vol. 45 (18), pp. 3972-83.