Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Autor: Chen, Ming-Huei, Raffield, Laura M, Mousas, Abdou, Sakaue, Saori, Huffman, Jennifer E, Moscati, Arden, Trivedi, Bhavi, Jiang, Tao, Akbari, Parsa, Vuckovic, Dragana, Bao, Erik L, Zhong, Xue, Manansala, Regina, Laplante, Véronique, Chen, Minhui, Lo, Ken Sin, Qian, Huijun, Lareau, Caleb A, Beaudoin, Mélissa, Hunt, Karen A, Akiyama, Masato, Bartz, Traci M, Ben-Shlomo, Yoav, Beswick, Andrew, Bork-Jensen, Jette, Bottinger, Erwin P, Brody, Jennifer A, van Rooij, Frank JA, Chitrala, Kumaraswamynaidu, Cho, Kelly, Choquet, Hélène, Correa, Adolfo, Danesh, John, Di Angelantonio, Emanuele, Dimou, Niki, Ding, Jingzhong, Elliott, Paul, Esko, Tõnu, Evans, Michele K, Floyd, James S, Broer, Linda, Grarup, Niels, Guo, Michael H, Greinacher, Andreas, Haessler, Jeff, Hansen, Torben, Howson, Joanna MM, Huang, Qin Qin, Huang, Wei, Jorgenson, Eric, Kacprowski, Tim, Kähönen, Mika, Kamatani, Yoichiro, Kanai, Masahiro, Karthikeyan, Savita, Koskeridis, Fotis, Lange, Leslie A, Lehtimäki, Terho, Lerch, Markus M, Linneberg, Allan, Liu, Yongmei, Lyytikäinen, Leo-Pekka, Manichaikul, Ani, Martin, Hilary C, Matsuda, Koichi, Mohlke, Karen L, Mononen, Nina, Murakami, Yoshinori, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ouwehand, Willem H, Pankratz, Nathan, Pedersen, Oluf, Preuss, Michael, Psaty, Bruce M, Raitakari, Olli T, Roberts, David J, Rich, Stephen S, Rodriguez, Benjamin AT, Rosen, Jonathan D, Rotter, Jerome I, Schubert, Petra, Spracklen, Cassandra N, Surendran, Praveen, Tang, Hua, Tardif, Jean-Claude, Trembath, Richard C, Ghanbari, Mohsen, Völker, Uwe, Völzke, Henry, Watkins, Nicholas A, Zonderman, Alan B, VA Million Veteran Program, Wilson, Peter WF, Li, Yun, Butterworth, Adam S, Gauchat, Jean-François, Chiang, Charleston WK, Li, Bingshan

Publikováno v: Cell, vol 182, iss 5

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::03846a24fb250a804c0c8a241fe7071a
https://escholarship.org/uc/item/5rt484d9

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Autor: Chen MH; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Mousas A; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan., Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Moscati A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Trivedi B; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK., Jiang T; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Akbari P; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK., Vuckovic D; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Bao EL; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA., Zhong X; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA., Manansala R; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA., Laplante V; Département de Pharmacologie et Physiologie, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada., Chen M; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA., Lo KS; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada., Qian H; Department of Statistics and Operation Research, University of North Carolina, Chapel Hill, NC 27599, USA., Lareau CA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA., Beaudoin M; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada., Hunt KA; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8581, Japan., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA 98101, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK., Beswick A; Translational Health Sciences, Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Hasso-Plattner-Institut, Universität Potsdam, Potsdam 14469, Germany., Brody JA; Department of Medicine, University of Washington, Seattle, WA 98101, USA., van Rooij FJA; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands., Chitrala K; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA; Department of Medicine, Division on Aging, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Choquet H; Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Di Angelantonio E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Dimou N; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon 69008, France; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., Ding J; Department of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Imperial Biomedical Research Centre, Imperial College London and Imperial College NHS Healthcare Trust, London SW7 2AZ, UK; Medical Research Council-Public Health England Centre for Environment, Imperial College London, London SW7 2AZ, UK; UK Dementia Research Institute, Imperial College London, London SW7 2AZ, UK; Health Data Research UK - London, London SW7 2AZ, UK., Esko T; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA., Floyd JS; Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA., Broer L; Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Guo MH; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA., Greinacher A; Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Howson JMM; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Novo Nordisk Research Centre Oxford, Innovation Building, Old Road Campus, Oxford OX3 7FZ, UK., Huang QQ; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai 201203, China., Jorgenson E; Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA., Kacprowski T; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany; Chair of Experimental Bioinformatics, Research Group Computational Systems Medicine, Technical University of Munich, Freising-Weihenstephan 85354, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan., Kanai M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Karthikeyan S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Koskeridis F; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland., Lerch MM; Department of Internal Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg 2000, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Liu Y; Duke Molecular Physiology Institute, Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27701, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA., Martin HC; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Matsuda K; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland., Murakami Y; Division of Molecular Pathology, The Institute of Medical Sciences, The University of Tokyo, Tokyo 108-8639, Japan., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nauck M; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany; Institue of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere 33521, Finland; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland., Ouwehand WH; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK; Department of Hematology, University of Cambridge, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Psaty BM; Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland., Roberts DJ; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK; Department of Haematology, Churchill Hospital, Oxford OX3 7LE, UK; NHS Blood and Transplant - Oxford Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA., Rodriguez BAT; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA., Rosen JD; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Schubert P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01002, USA., Surendran P; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Tang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA., Tardif JC; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada., Trembath RC; School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL, UK., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany., Völzke H; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Watkins NA; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA., Wilson PWF; Atlanta VA Medical Center, Decatur, GA 30033, USA., Li Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA., Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK., Gauchat JF; Département de Pharmacologie et Physiologie, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada., Chiang CWK; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; Quantitative and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA., Li B; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Astle WJ; MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Strangeways Laboratory, Cambridge CB1 8RN, UK., Evangelou E; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK., van Heel DA; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Laboratory of Statistical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan., Soranzo N; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Department of Hematology, University of Cambridge, Cambridge CB2 0PT, UK., Johnson AD; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA 98109, USA., Auer PL; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. Electronic address: pauer@uwm.edu., Lettre G; Montreal Heart Institute, Montreal, QC H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada. Electronic address: guillaume.lettre@umontreal.ca.

Publikováno v: Cell [Cell] 2020 Sep 03; Vol. 182 (5), pp. 1198-1213.e14.