Zobrazeno 1 - 10
of 520
pro vyhledávání: '"Kosik KS"'
Autor:
Piedrahita, D, Fredy Castro-Alvarez, J, Boudreau, RL, Villegas-Lanau, A, Kosik, KS, Carlos Gallego-Gomez, J, Patricia Cardona-Gomez, G
Publikováno v:
Piedrahita, D; Fredy Castro-Alvarez, J; Boudreau, RL; Villegas-Lanau, A; Kosik, KS; Carlos Gallego-Gomez, J; et al.(2016). beta-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. FRONTIERS IN CELLULAR NEUROSCIENCE, 9. doi: 10.3389/fncel.2015.00498. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/9c2962fd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::79497ececf31cb611cce349ee0bdfab6
http://www.escholarship.org/uc/item/9c2962fd
http://www.escholarship.org/uc/item/9c2962fd
Autor:
Omura, T, Omura, K, Tedeschi, A, Riva, P, Painter, MW, Rojas, L, Martin, J, Lisi, V, Huebner, EA, Latremoliere, A, Yin, Y, Barrett, LB, Singh, B, Lee, S, Crisman, T, Gao, F, Li, S, Kapur, K, Geschwind, DH, Kosik, KS, Coppola, G, He, Z, Carmichael, ST, Benowitz, LI, Costigan, M, Woolf, CJ
Publikováno v:
Omura, T; Omura, K; Tedeschi, A; Riva, P; Painter, MW; Rojas, L; et al.(2014). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. doi: 10.1016/j.neuron.2015.05.005. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5f9010t8
© 2015 Elsevier Inc. Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::44c7d6f16fa0a19dbfadd579aac9a04a
http://www.escholarship.org/uc/item/5f9010t8
http://www.escholarship.org/uc/item/5f9010t8
Publikováno v:
Science translational medicine, vol 6, iss 241
Lo, AW; Ho, C; Cummings, J; & Kosik, KS. (2014). Parallel discovery of Alzheimer's therapeutics. Science Translational Medicine, 6(241). doi: 10.1126/scitranslmed.3008228. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/0jv2g2xp
Lo, AW; Ho, C; Cummings, J; & Kosik, KS. (2014). Parallel discovery of Alzheimer's therapeutics. Science Translational Medicine, 6(241). doi: 10.1126/scitranslmed.3008228. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/0jv2g2xp
As the prevalence of Alzheimer's disease (AD) grows, so do the costs it imposes on society. Scientific, clinical, and financial interests have focused current drug discovery efforts largely on the single biological pathway that leads to amyloid depos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a5e1be23d17cc39a9c59178d7e253b26
https://escholarship.org/uc/item/0jv2g2xp
https://escholarship.org/uc/item/0jv2g2xp
Publikováno v:
Castro-Alvarez, JF; Alejandro Uribe-Arias, S; Kosik, KS; & Cardona-Gómez, GP. (2014). Long-and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Frontiers in Aging Neuroscience, 6(SEP). doi: 10.3389/fnagi.2014.00243. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/1c8459zr
© 2014 Castro-Alvarez, Uribe-Arias, Kosik and Cardona-Gómez. CDK5 is a member of the cyclin-dependent kinase family with diverse functions in both the developing and mature nervous system. The inappropriate activation of CDK5 due to the proteolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::1528ba8c38d261cbd1de6bb65e7eaca6
http://www.escholarship.org/uc/item/1c8459zr
http://www.escholarship.org/uc/item/1c8459zr
Autor:
Kosik, KS
Publikováno v:
Kosik, KS. (2013). Study neuron networks to tackle Alzheimer's. Nature, 503(7474), 31-32. doi: 10.1038/503031a. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/4cb3c3dw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::82bec587b82a5d739ed8767fac63c581
http://www.escholarship.org/uc/item/4cb3c3dw
http://www.escholarship.org/uc/item/4cb3c3dw
Autor:
Giraldo, M, Lopera, F, Siniard, AL, Corneveaux, JJ, Schrauwen, I, Carvajal, J, Muñoz, C, Ramirez-Restrepo, M, Gaiteri, C, Myers, AJ, Caselli, RJ, Kosik, KS, Reiman, EM, Huentelman, MJ
Publikováno v:
Neurobiology of aging, vol 34, iss 8
Giraldo, M; Lopera, F; Siniard, AL; Corneveaux, JJ; Schrauwen, I; Carvajal, J; et al.(2013). Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiology of Aging, 34(8), e1-.e18. doi: 10.1016/j.neurobiolaging.2013.02.016. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/9wp8v03r
Giraldo, M; Lopera, F; Siniard, AL; Corneveaux, JJ; Schrauwen, I; Carvajal, J; et al.(2013). Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiology of Aging, 34(8), e1-.e18. doi: 10.1016/j.neurobiolaging.2013.02.016. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/9wp8v03r
Recent evidence suggests that rare genetic variants within the TREM2 gene are associated with increased risk of Alzheimer's disease. TREM2 mutations are the genetic basis for a condition characterized by polycystic lipomembranous osteodysplasia with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15fd207f650b2a81cf8cd212a638c0d9
https://escholarship.org/uc/item/9wp8v03r
https://escholarship.org/uc/item/9wp8v03r
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