Výsledky vyhledávání - "Kosha, Ruparel"

Akademický článek

Computer-vision analysis of craniofacial dysmorphology in 22q11.2 deletion syndrome and psychosis spectrum disorders

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Background Minor physical anomalies (MPAs) are congenital morphological abnormalities linked to disruptions of fetal development. MPAs are common in 22q11.2 deletion syndrome (22q11DS) and psychosis spectrum disorders (PS) and likely represe

Externí odkaz: https://doaj.org/article/dc8c12b789804ab18fb63538360a9af8

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Akademický článek

Relationship of ventral striatum activation during effort discounting to clinical amotivation severity in schizophrenia

Autor: Greer E. Prettyman, Joseph W. Kable, Paige Didier, Sheila Shankar, Theodore D. Satterthwaite, Christos Davatzikos, Warren B. Bilker, Mark A. Elliott, Kosha Ruparel, Daniel H. Wolf

Publikováno v: npj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)

Abstract Motivational deficits play a central role in disability due to negative symptoms of schizophrenia (SZ), but limited pathophysiological understanding impedes critically needed therapeutic development. We applied an fMRI Effort Discounting Tas

Externí odkaz: https://doaj.org/article/a0155da9ab6d4263a3f7852965137986

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Akademický článek

Stability of polygenic scores across discovery genome-wide association studies

Autor: Laura M. Schultz, Alison K. Merikangas, Kosha Ruparel, Sébastien Jacquemont, David C. Glahn, Raquel E. Gur, Ran Barzilay, Laura Almasy

Publikováno v: HGG Advances, Vol 3, Iss 2, Pp 100091- (2022)

Summary: Polygenic scores (PGS) are commonly evaluated in terms of their predictive accuracy at the population level by the proportion of phenotypic variance they explain. To be useful for precision medicine applications, they also need to be evaluat

Externí odkaz: https://doaj.org/article/ba3fded5201e4e238d2d93905cda0356

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Akademický článek

Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders

Autor: Min K. Souther, Daniel H. Wolf, Rebecca Kazinka, Sangil Lee, Kosha Ruparel, Mark A. Elliott, Anna Xu, Matthew Cieslak, Greer Prettyman, Theodore D. Satterthwaite, Joseph W. Kable

Publikováno v: NeuroImage: Clinical, Vol 36, Iss , Pp 103227- (2022)

Deficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for an association be

Externí odkaz: https://doaj.org/article/e3a3326fccb3418a9b4633a58dec274e

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Psychosis spectrum features, neurocognition and functioning in a longitudinal study of youth with 22q11.2 deletion syndrome

Autor: Raquel E. Gur, Donna M. McDonald-McGinn, Tyler M. Moore, R. Sean Gallagher, Emily McClellan, Lauren White, Kosha Ruparel, Noah Hillman, T. Blaine Crowley, Daniel E. McGinn, Elaine Zackai, Beverly S. Emanuel, Monica E. Calkins, David R. Roalf, Ruben C. Gur

Publikováno v: Psychological Medicine. :1-10

Background Neuropsychiatric disorders are common in 22q11.2 Deletion Syndrome (22q11DS) with about 25% of affected individuals developing schizophrenia spectrum disorders by young adulthood. Longitudinal evaluation of psychosis spectrum features and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f64b8c7827e3e02c383d451549e953d
https://doi.org/10.1017/s0033291723000259

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A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome

Autor: T. Blaine Crowley, Beverly S. Emanuel, Khaled Khairy, Walter J. Akers, Stanislav S. Zakharenko, R. Sean Gallagher, Jeffrey Steinberg, J. Eric Schmitt, Shahinur Alam, David R. Roalf, Ruben C. Gur, Donna M. McDonald-McGinn, Raquel E. Gur, Kosha Ruparel, Tae-Yeon Eom, Aaron Alexander-Bloch, John J. DeBevits

Publikováno v: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 8:79-90

The presence of a 22q11.2 microdeletion (22q11.2 deletion syndrome [22q11DS]) ranks among the greatest known genetic risk factors for the development of psychotic disorders. There is emerging evidence that the cerebellum is important in the pathophys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b685c5d0611a2a0d61f0712bd0f785
https://doi.org/10.1016/j.bpsc.2021.11.008

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Akademický článek

Development of a computerised neurocognitive battery for children and adolescents with HIV in Botswana: study design and protocol for the Ntemoga study

Autor: Elizabeth D Lowenthal, J Cobb Scott, Amelia E Van Pelt, Allison M Port, Lucky Njokweni, Ruben C Gur, Tyler M Moore, Onkemetse Phoi, Ontibile Tshume, Mogomotsi Matshaba, Kosha Ruparel, Jennifer Chapman

Publikováno v: BMJ Open, Vol 10, Iss 8 (2020)

Introduction Neurodevelopmental delays and cognitive impairments are common in youth living with HIV. Unfortunately, in resource-limited settings, where HIV infection impacts millions of children, cognitive and neurodevelopmental disorders commonly g

Externí odkaz: https://doaj.org/article/5f5585ddf6b24003acfca31cf83d322b

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Akademický článek

Optimization of energy state transition trajectory supports the development of executive function during youth

Publikováno v: eLife, Vol 9 (2020)

Executive function develops during adolescence, yet it remains unknown how structural brain networks mature to facilitate activation of the fronto-parietal system, which is critical for executive function. In a sample of 946 human youths (ages 8-23y)

Externí odkaz: https://doaj.org/article/1028cda0c9cd4a06814aa0b0410414f0

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