Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kosei Yoshihara"'
Autor:
Hiroyoshi Yamada, Yoshiaki Shimada, Keitaro Kadono, Susumu Yamaki, Akira Nagashima, Mitsuhiro Kondo, Kosei Yoshihara
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:6024-6038
Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted structural optimization of the glycine amide derivative 1, which we previously reported as a novel VAP-1 inhibitor, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2768d2583b652416c99d230030fd786d
https://doi.org/10.1016/j.bmc.2017.09.036
https://doi.org/10.1016/j.bmc.2017.09.036
Autor:
Ayako Moritomo, Kosei Yoshihara, Susumu Yamaki, Mitsuhiro Kondo, Yuji Koga, Yoshiaki Shimada, Keitaro Kadono, Akira Nagashima
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4110-4122
Vascular adhesion protein-1 (VAP-1) is a promising therapeutic target for the treatment of diabetic nephropathy. Here, we conducted optimization studies of our lead compound 1 , which we previously reported as a novel VAP-1 inhibitor, to enhance the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d75a7c95be840d0bbae08b73349c530
https://doi.org/10.1016/j.bmc.2017.05.059
https://doi.org/10.1016/j.bmc.2017.05.059
Autor:
Takafumi Akabane, Akira Nagashima, Ayako Moritomo, Jiro Fujiyasu, Susumu Yamaki, Kosei Yoshihara, Keitaro Kadono, Masahiro Neya, Suzuki Daisuke, Mitsuhiro Kondo
Publikováno v:
Bioorganicmedicinal chemistry. 25(1)
Vascular Adhesion Protein-1 (VAP-1) is a promising therapeutic target for the treatment of several inflammatory-related diseases including diabetic microvascular complication. We identified glycine amide derivative 3 as a novel structure with moderat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919d6aec64d0e952cb11d45e8532f307
https://pubmed.ncbi.nlm.nih.gov/27810440
https://pubmed.ncbi.nlm.nih.gov/27810440
Autor:
Akinori Yamamoto, Kenzi Hori, Shinji Marumo, Akikazu Kakehi, Takeshi Nishiguchi, Kosei Yoshihara, Akio Kamimura
Publikováno v:
The Journal of Organic Chemistry. 57:5403-5413
4,5-Disubstituted 3-formyl-Δ 2 -isoxazolines undergo the aldol, allylation, and carbonyl ene reactions in the presence of appropriate Lewis acid to give the adducts with an effective 1,3-asymmetric induction. The stereoselectivity of the reaction ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b5f8646d8d87cacae98d81a854e6cb
https://doi.org/10.1021/jo00046a023
https://doi.org/10.1021/jo00046a023