Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A

Autor: Kosei Ishimaru, Masataka Ikeda, Hiroko Deguchi Miyamoto, Shun Furusawa, Ko Abe, Masatsugu Watanabe, Takuya Kanamura, Satoshi Fujita, Ryohei Nishimura, Takayuki Toyohara, Shouji Matsushima, Tomoko Koumura, Ken‐ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui, Tomomi Ide

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024)

Background Ferroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyclospori

Externí odkaz: https://doaj.org/article/dbaf2db9f0a143d98668818ad9250cb5

Ethoxyquin is a Competent Radical-Trapping Antioxidant for Preventing Ferroptosis in Doxorubicin Cardiotoxicity

Autor: Tomonori, Tadokoro, Masataka, Ikeda, Ko, Abe, Tomomi, Ide, Hiroko Deguchi, Miyamoto, Shun, Furusawa, Kosei, Ishimaru, Masatsugu, Watanabe, Akihito, Ishikita, Shouji, Matsushima, Tomoko, Koumura, Ken-Ichi, Yamada, Hirotaka, Imai, Hiroyuki, Tsutsui

Publikováno v: Journal of Cardiovascular Pharmacology. 80:690-699

Doxorubicin (DOX) is an effective anti-cancer agent for various malignancies. Nevertheless, it has a side effect of cardiotoxicity, referred to as doxorubicin-induced cardiomyopathy (DIC), that is associated with a poorer prognosis. This cardiotoxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8ee12945d4d08b02d838c5a727d192
https://doi.org/10.1097/fjc.0000000000001328

Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis

Autor: Ko Abe, Masataka Ikeda, Tomomi Ide, Tomonori Tadokoro, Hiroko Deguchi Miyamoto, Shun Furusawa, Yoshitomo Tsutsui, Ryo Miyake, Kosei Ishimaru, Masatsugu Watanabe, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui

Publikováno v: Science Signaling. 15

Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by iron overload and excessive lipid peroxidation, plays a pivotal rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105837123fbbe96f06c1d33e12b2fa3
https://doi.org/10.1126/scisignal.abn8017

Excessive Hypoxia‐Inducible Factor‐1α Expression Induces Cardiac Rupture via p53‐Dependent Apoptosis After Myocardial Infarction

Autor: Midori Sato, Kosuke Okabe, Ko Abe, Shouji Matsushima, Akihito Ishikita, Masataka Ikeda, Shun Furusawa, Hiroyuki Tsutsui, Tomomi Ide, Tomonori Tadokoro, Kosei Ishimaru, Soichiro Ikeda, Hiroko Deguchi Miyamoto

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Apoptosis plays a pivotal role in cardiac rupture after myocardial infarction (MI), and p53 is a key molecule in apoptosis during cardiac rupture. Hif‐1α (hypoxia‐inducible factor‐1α), upregulated under hypoxia, is a known p53 indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12130453020f8bc0f7b2ac1e2f57446
https://doi.org/10.1161/jaha.121.020895