Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kosea S. Frederick"'
Autor:
Cathrine Leonowens, Vanessa González-Pérez, Mary F. Paine, Michael Fisher, Yolanda Scarlett, Kosea S. Frederick, Emily J. Cox, Dan-Dan Tian
Publikováno v:
Drug Metabolism and Disposition. 47:724-731
Midazolam is a widely used index substrate for assessing effects of xenobiotics on CYP3A activity. A previous study involving human hepatocytes showed the primary route of midazolam metabolism, 1'-hydroxylation, shifted to N-glucuronidation in the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a61709c848ace4772e14bb7b14a9da7
https://doi.org/10.1124/dmd.119.087007
https://doi.org/10.1124/dmd.119.087007
Autor:
Dan-Dan, Tian, Cathrine, Leonowens, Emily J, Cox, Vanessa, González-Pérez, Kosea S, Frederick, Yolanda V, Scarlett, Michael B, Fisher, Mary F, Paine
Publikováno v:
Drug Metab Dispos
Midazolam is a widely used index substrate for assessing effects of xenobiotics on CYP3A activity. A previous study involving human hepatocytes showed the primary route of midazolam metabolism, 1′-hydroxylation, shifted to N-glucuronidation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c14447d8066aae49fd28ca8882cd05d
https://pubmed.ncbi.nlm.nih.gov/31028057
https://pubmed.ncbi.nlm.nih.gov/31028057
Autor:
Steven G. Terra, Mark A. West, Charles J. Rotter, Amit S. Kalgutkar, Robert L. Walsky, Bo Feng, Manthena V.S. Varma, Renato J. Scialis, Kosea S. Frederick, Omar L. Francone, James R. Gosset, Theunis C. Goosen, Danny Chen
Publikováno v:
Xenobiotica. 43:963-972
1. 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), an agonist of the peroxisome proliferator-activated receptor alpha, has been evaluated in the clinic to treat dyslipidemia and type 2 diabetes mellitus. Herein, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e370b585737a88efde05476bab223865
https://doi.org/10.3109/00498254.2013.791004
https://doi.org/10.3109/00498254.2013.791004
Autor:
John R. Soglia, Hao Sun, Jonathan N. Bauman, Zhuang Miao, Jianke Li, Angel Guzman-Perez, Kenneth J. DiRico, Tim F. Ryder, Scott W. Bagley, Kosea S. Frederick, Bruce M. Bechle, Sabrina X. Zhao, Michael P. Zawistoski, Daniel P. Walker, Kevin K.-C. Liu, Mary Theresa Didiuk, Amit S. Kalgutkar, Joel Morris, Robert M. Oliver, Ryan Michael Kelley, John William Benbow, David A. Griffith, Chandra Prakash
Publikováno v:
Chemical Research in Toxicology. 23:1115-1126
The synthesis and structure-activity relationship studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones as antagonists of the human calcium receptor (CaSR) have been recently disclosed [ Didiuk et al. ( 2009 ) Bioorg. Med. Chem. Lett. 19 , 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24e5e5f32d0c8dbdd97463c65363b37
https://doi.org/10.1021/tx100137n
https://doi.org/10.1021/tx100137n
Autor:
Delvin R. Knight, Weifan Weng, Andrew Robertson, Amit S. Kalgutkar, Ronald P. Gladue, Patricia-Ann Bourassa, Kosea S. Frederick, Andrew H. Smith, Robert J. Aiello, Bret D. Perry
Publikováno v:
Atherosclerosis. 208:370-375
Objective The CCR2 receptor plays a crucial role in monocyte recruitment and has been implicated as a contributing factor to atherosclerosis. CCR2 receptor deletion leads to significant inhibition of lesion development. Our objective was to determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4873806ad28e8886cb07500f3b8bfbd
https://doi.org/10.1016/j.atherosclerosis.2009.08.017
https://doi.org/10.1016/j.atherosclerosis.2009.08.017
Autor:
Rochelle J. Mireles, Matthew D. Troutman, Bo Feng, Jonathan Chupka, Kosea S. Frederick, Sarah Kempshall, Katherine S. Fenner, Amit S. Kalgutkar
Publikováno v:
Journal of Pharmaceutical Sciences. 98:4914-4927
The utility of the diaminoquinazoline derivative CP-100,356 as an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat. CP-100,356 was devoid of inhibition (IC(50) >50 microM) against major human P450 enzymes inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c674dd3adfad08ba72b0ae03578f54
https://doi.org/10.1002/jps.21756
https://doi.org/10.1002/jps.21756
Autor:
Scott W. Bagley, Hang T. Nguyen, Kosea S. Frederick, Michael P. Zawistoski, Kenneth J. DiRico, Vishwas M. Paralkar, Xiaojing Yang, Hua Gao, Thanh V. Olson, Keith Riccardi, Stephanie Santucci, F. Christopher Bi, Tristan S. Maurer, Matthew Corbett, Daniel P. Walker, Ryan Michael Kelley, Robert M. Oliver, John William Benbow, David R. Healy, Joseph DiBrinno, Amit S. Kalgutkar, Kevin K.-C. Liu, Mei Li, Syed Ahmed, Mary Theresa Didiuk, Joel Morris, Chiliu Chen, William M. Hungerford, Bruce M. Bechle, Yuan Zeng, Jianke Li, Angel Guzman-Perez, David A. Griffith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4555-4559
Synthesis and structure-activity relationship (SAR) studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones, a novel class of calcium receptor antagonists is described with particular emphasis on optimization of the pharmacokinetic/pharmacodyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72173b66555bd956618fe8850eb6bbd3
https://doi.org/10.1016/j.bmcl.2009.07.004
https://doi.org/10.1016/j.bmcl.2009.07.004
Autor:
Amit S. Kalgutkar, Edna F. Choo, Heather L. Hatch, Yi-an Bi, Hang T. Nguyen, David B. Duignan, Kosea S. Frederick, Sabrina X. Zhao, Scott D. Campbell, Rouchelle J. Mireles, Bo Feng, Diana C. Kazolias, Ralph E. Davidson
Publikováno v:
Drug Metabolism and Disposition. 35:2111-2118
The role of transporters in the disposition of (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid (CP-671,305), an orally active inhibitor of phosphodiesterase-4, was examined. In bile duct-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731758e9765afeec53807ae21ec7d2e5
https://doi.org/10.1124/dmd.107.016162
https://doi.org/10.1124/dmd.107.016162
Publikováno v:
The AAPS Journal. 8:E433-E442
Biochanin A (BCA) is a dietary isoflavone present in legumes, most notably red clover, and in many herbal dietary supplements. BCA has been reported to have chemopreventive properties and is metabolized to the isoflavone genistein (GEN), BCA conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e09adb8719310c30d064ca4eff3aa40
https://doi.org/10.1208/aapsj080351
https://doi.org/10.1208/aapsj080351
Autor:
Amit S. Kalgutkar, Ravi Shanker Garigipati, Lee A. Morehouse, Bruce Allen Lefker, Catherine M. Ambler, Heather L. Hatch, David Austen Perry, Xiao Hu, George Chang, Omar L. Francone, Kosea S. Frederick, Ronald W. Clark
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 44(7)
1. Elaborate studies of cholesteryl ester transfer protein (CETP) polymorphisms and genetic deficiency in humans suggest direct links between CETP, high-density lipoprotein cholesterol (HDL-c) levels and coronary heart diseases. The hypothesis that C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61dc863432546b8189030947aee413
https://pubmed.ncbi.nlm.nih.gov/24380613
https://pubmed.ncbi.nlm.nih.gov/24380613