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A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta1-42 Peptide in the Brain and Leads to Alzheimer's Disease-Relevant Cognitive Changes in a Mouse Model.

Autor: Acharya NK; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Cell Biology and Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Center for Neurotrauma, Neurodegeneration and Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Biomarker Discovery Center, New Jersey Institute for Successful Aging (NJISA), Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA.; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Rowan University, Glassboro, NJ, USA., Grossman HC; Department of Psychology, Rutgers University, Piscataway, NJ, USA., Clifford PM; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; HNL Lab Medicine, Allentown, PA, USA., Levin EC; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Graduate Medical Education, Bayhealth Medical Center, Dover, DE, USA., Light KR; Department of Psychology, Barnard College of Columbia University, New York, NY, USA., Choi H; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA., Swanson Ii RL; Center for Neurotrauma, Neurodegeneration and Restoration, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Rehab Medicine Service, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Physical Medicine and Rehabilitation, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Kosciuk MC; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA., Venkataraman V; Department of Cell Biology and Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Academic and Student Affairs, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA., Libon DJ; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Department of Psychology, Rowan University, Glassboro, NJ, USA., Matzel LD; Department of Psychology, Rutgers University, Piscataway, NJ, USA., Nagele RG; Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.; Biomarker Discovery Center, New Jersey Institute for Successful Aging (NJISA), Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA.; Rowan-Virtua Graduate School of Biomedical Sciences, Stratford, NJ, USA.; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Rowan University, Glassboro, NJ, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (1), pp. 163-186.

Evidence that Brain-Reactive Autoantibodies Contribute to Chronic Neuronal Internalization of Exogenous Amyloid-β1-42 and Key Cell Surface Proteins During Alzheimer's Disease Pathogenesis.

Autor: Goldwaser EL; University of Maryland Medical Center and Sheppard Pratt Health System, Department of Psychiatry, Baltimore, MD, USA.; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA., Acharya NK; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA.; Department of Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA., Wu H; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA., Godsey GA; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA., Sarkar A; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA., DeMarshall CA; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA., Kosciuk MC; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Department of Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA., Nagele RG; Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.; Graduate School of Biomedical Sciences, Rowan University, Stratford, NJ, USA.; Department of Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine, Stratford, NJ, USA.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 74 (1), pp. 345-361.

Mechanical stress regulates transport in a compliant 3D model of the blood-brain barrier.

Autor: Partyka PP; Department of Biomedical Engineering, Rowan University, United States., Godsey GA; School of Biomedical Sciences, Rowan University, United States., Galie JR; Department of Physics, Camden County College, United States., Kosciuk MC; School of Osteopathic Medicine, Rowan University, United States., Acharya NK; School of Osteopathic Medicine, Rowan University, United States., Nagele RG; School of Biomedical Sciences, Rowan University, United States; School of Osteopathic Medicine, Rowan University, United States., Galie PA; Department of Biomedical Engineering, Rowan University, United States. Electronic address: galie@rowan.edu.

Publikováno v: Biomaterials [Biomaterials] 2017 Jan; Vol. 115, pp. 30-39. Date of Electronic Publication: 2016 Nov 17.

Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease.

Autor: Nagele EP; Biomarker Discovery Center, New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, Stratford, NJ, USA. nagelero@umdnj.edu, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG

Publikováno v: PloS one [PLoS One] 2013 Apr 02; Vol. 8 (4), pp. e60726. Date of Electronic Publication: 2013 Apr 02 (Print Publication: 2013).