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of 2
pro vyhledávání: '"Kosala N. Amarasinghe"'
Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response
Autor:
Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1584-1592 (2022)
The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activa
Externí odkaz:
https://doaj.org/article/9c0a764ffe7b4efaad7c3bc6b85214d1
Autor:
Kosala N. Amarasinghe, Leonardo De Maria, Christian Tyrchan, Leif A. Eriksson, Jens Sadowski, Dušan Petrović
Publikováno v:
Journal of chemical information and modeling. 62(12)
Peptides are an important modality in drug discovery. While current peptide optimization focuses predominantly on the small number of natural and commercially available non-natural amino acids, the chemical spaces available for small molecule drug di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b77b75577684db94eb0b2b9c4c58ad2
https://pubmed.ncbi.nlm.nih.gov/35699524
https://pubmed.ncbi.nlm.nih.gov/35699524