Drugging an undruggable pocket on KRAS

Autor: Kesslera, Dirk, Gmachla, Michael, Mantoulidisa, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug 01. 116(32), 15823-15829.

Externí odkaz: https://www.jstor.org/stable/26848431

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Front Cover: A 3D‐Printed Open Access Photoreactor Designed for Versatile Applications in Photoredox‐ and Photoelectrochemical Synthesis*.

Autor: Schiel, Florian, Peinsipp, Christoph, Kornigg, Stefan, Böse, Dietrich

Publikováno v: ChemPhotoChem; May2021, Vol. 5 Issue 5, p390-390, 1p

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.

Autor: Martin LJ; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Koegl M; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Bader G; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Cockcroft XL; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Fedorov O; SGC, University of Oxford , Oxford OX3 7DQ, United Kingdom., Fiegen D; Boehringer Ingelheim Pharma GmbH & Co KG , Biberach 88400, Germany., Gerstberger T; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Hofmann MH; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Hohmann AF; Cold Spring Harbor Laboratory , Cold Spring Harbor, New York 11724, United States., Kessler D; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Knapp S; SGC, University of Oxford , Oxford OX3 7DQ, United Kingdom., Knesl P; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Kornigg S; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Müller S; SGC, University of Oxford , Oxford OX3 7DQ, United Kingdom., Nar H; Boehringer Ingelheim Pharma GmbH & Co KG , Biberach 88400, Germany., Rogers C; SGC, University of Oxford , Oxford OX3 7DQ, United Kingdom., Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Schaaf O; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Steurer S; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Tallant C; SGC, University of Oxford , Oxford OX3 7DQ, United Kingdom., Vakoc CR; Cold Spring Harbor Laboratory , Cold Spring Harbor, New York 11724, United States., Zeeb M; Boehringer Ingelheim Pharma GmbH & Co KG , Biberach 88400, Germany., Zoephel A; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Pearson M; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., Boehmelt G; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria., McConnell D; Boehringer Ingelheim RCV GmbH & Co KG , Vienna 1121, Austria.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 May 26; Vol. 59 (10), pp. 4462-75. Date of Electronic Publication: 2016 Mar 10.