Výsledky vyhledávání - "Kornfeld Edmund C"

Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline

Autor: Ray W. Fuller, Norman R. Mason, Robert Daniel Titus, Hynes, Hahn Ra, Kornfeld Edmund C, E. B. Smalstig, Foreman Mark Mortensen, David T.W. Wong, Noel D. Jones, James A. Clemens

Publikováno v: Journal of Medicinal Chemistry. 26:1112-1116

The title compound (+/-)-5 (R = Pro) (LY141865) has been resolved into a (-) isomer and a (+) isomer as the D- and L-tartrate salts, respectively. Biological studies have shown that dopamine agonist activity is a property of only the (-) isomer. Crys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b3df3a35d95f8a1a15b899ab11af60
https://doi.org/10.1021/jm00362a005

Zobrazit plný text záznamu

Elevation of acetylcholine levels in striatum of rat brain by LY163502, trans−(−)−5,5a,6,7,8,9a,10-octahydro-6-propylpyrimido〈4,5−g〉quinolin-2- amine dihydrochloride, a potent and stereospecific dopamine (D2) agonist

Autor: David T. Wong, Frank P. Bymaster, Nichols Cynthia Lynn, Kornfeld Edmund C, Leroy R. Reid

Publikováno v: Life Sciences. 38:317-322

LY163502, a partial ergoline and a trans-levorotatory enantiomer, does not stimulate adenylate cyclase in striatal membranes but inhibits 50% binding of 3H-apomorphine, 3H-pergolide and 3H-spiperone at 10, 13 and 151 nM (IC50), respectively. The race

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::403f41a0a782e04fc5d9d2f7897d5e29
https://doi.org/10.1016/0024-3205(86)90078-0

Zobrazit plný text záznamu

Effects of (8beta)-8-[methylthio)methyl]-6-propylergoline on dopaminergic function and brain dopamine turnover in rats

Autor: Bach Nicholas J, E. Barry Smalstig, James A. Clemens, Kornfeld Edmund C, Ray W. Fuller, Harold D. Snoddy

Publikováno v: Life sciences. 24(4)

(8β)-8-[(Methylthio)methyl]-6-propylergoline induced contralateral turning in rats with nigrostriatal lesions, lowered serum prolactin in reserpinized rats, and caused stereotyped hyperactivity. In addition to these functional effects typical of dop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877ce36f04a9e584fccb12a52c2688cf
https://pubmed.ncbi.nlm.nih.gov/34767

Zobrazit plný text záznamu

Synthesis and biological activity of 8-arylergolines

Autor: Douglas E. Dorman, Bach Nicholas J, Kornfeld Edmund C

Publikováno v: Journal of medicinal chemistry. 20(8)

9,10-Didehydro-6-methyl-8beta-arylergolines 2, in which the carboxyl group of lysergic acid and isolysergic acid is replaced by various aryl groups, were prepared in two steps by alkylation of aromatic substrates with the tetracyclic allylic alcohol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0643f59956298151cd3ca2fa89fd1e
https://pubmed.ncbi.nlm.nih.gov/561190

Zobrazit plný text záznamu

ChemInform Abstract: SYNTHESIS AND BIOLOGICAL ACTIVITY OF 8-ARYLERGOLINES

Autor: Douglas E. Dorman, Kornfeld Edmund C, Bach Nicholas J

Publikováno v: Chemischer Informationsdienst. 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9264286cbc4c9bbf60f129e8b674e137
https://doi.org/10.1002/chin.197749256

Zobrazit plný text záznamu

Inhibition of prolactin secretion by ergolines

Autor: E. Barrysmalstig, James A. Clemens, Bach Nicholas J, Carl Joseph Shaar, Kornfeld Edmund C

Publikováno v: Endocrinology. 94(4)

Peptide-containing ergot alkaloids and synthetic ergoline derivatives were administered to reserpine-treated male rats in order to evaluate their prolactin-inhibiting properties. Each compound was administered ip at a standard 50 ¼g/kg dose. The 9,1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995eb93f186ca756de508181a5032ea9
https://pubmed.ncbi.nlm.nih.gov/4818776

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání