Apoptosis signal-regulating kinase 1 inhibition in and models of pulmonary hypertension

Autor: Kathryn S. Wilson, Hanna Buist, Kornelija Suveizdyte, John T. Liles, Grant R. Budas, Colin Hughes, Margaret R. MacLean, Martin Johnson, Alistair C. Church, Andrew J. Peacock, David J. Welsh

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

Pulmonary arterial hypertension, group 1 of the pulmonary hypertension disease family, involves pulmonary vascular remodelling, right ventricular dysfunction and cardiac failure. Oxidative stress, through activation of mitogen-activated protein kinas

Externí odkaz: https://doaj.org/article/6525394d6a864924aa813898fecdb00f

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Autor: Leo Swadling, Laura J. Pallett, Mariana O. Diniz, Josephine M. Baker, Oliver E. Amin, Kerstin A. Stegmann, Alice R. Burton, Nathalie M. Schmidt, Anna Jeffery-Smith, Nekisa Zakeri, Kornelija Suveizdyte, Farid Froghi, Giuseppe Fusai, William M. Rosenberg, Brian R. Davidson, Anna Schurich, A. Katharina Simon, Mala K. Maini

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 687-698.e6 (2020)

Summary: Tissue-resident memory T cells have critical roles in long-term pathogen and tumor immune surveillance in the liver. We investigate the role of autophagy in equipping human memory T cells to acquire tissue residence and maintain functionalit

Externí odkaz: https://doaj.org/article/424ef329fece490388a8227ae3fca83e

NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

Autor: Mariana O. Diniz, Anna Schurich, Senthil K. Chinnakannan, Marion Duriez, Kerstin A. Stegmann, Jessica Davies, Stephanie Kucykowicz, Kornelija Suveizdyte, Oliver E. Amin, Frances Alcock, Tamsin Cargill, Eleanor Barnes, Mala K. Maini

Publikováno v: Diniz, M O, Schurich, A, Chinnakannan, S K, Duriez, M, Stegmann, K A, Davies, J, Kucykowicz, S, Suveizdyte, K, Amin, O E, Alcock, F, Cargill, T, Barnes, E & Maini, M K 2022, ' NK cells limit therapeutic vaccine–induced CD8 + T cell immunity in a PD-L1–dependent manner ', Science Translational Medicine, vol. 14, no. 640, eabi4670 . https://doi.org/10.1126/scitranslmed.abi4670

A better understanding of mechanisms that regulate CD8 + T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enhanced antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b8a4db370a666b93d46c902bd6ad2
https://kclpure.kcl.ac.uk/ws/files/175375334/NK_cells_limit_therapeutic_DINIZ_Publishedonline13April2022_GREEN_AAM.pdf

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVD-19 respiratory disease

Autor: Bavithra Vijayakumar, Karim Boustani, Patricia P. Ogger, Artemis Papadaki, James Tonkin, Christopher M. Orton, Poonam Ghai, Kornelija Suveizdyte, Richard J. Hewitt, Sujal R. Desai, Anand Devaraj, Robert J. Snelgrove, Philip L. Molyneaux, Justin L. Garner, James E. Peters, Pallav L. Shah, Clare M. Lloyd, James A. Harker

Publikováno v: 556.e5
Immunity

Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airway and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c014aad34516807ea5564b5c2c38d1
http://hdl.handle.net/10044/1/94155

Apoptosis signal-regulating kinase 1 inhibition in in vivo and in vitro models of pulmonary hypertension

Autor: Andrew J. Peacock, Kathryn S. Wilson, Kornelija Suveizdyte, Grant R. Budas, Margaret R. MacLean, David J. Welsh, John T. Liles, Alistair C. Church, Hanna Buist, Martin Johnson, Colin Hughes

Publikováno v: Pulmonary Circulation

Pulmonary arterial hypertension, group 1 of the pulmonary hypertension disease family, involves pulmonary vascular remodelling, right ventricular dysfunction and cardiac failure. Oxidative stress, through activation of mitogen-activated protein kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa877a96663605e15412df26612d6e38
http://europepmc.org/articles/PMC7235684