Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kornelia M. Mikula"'
Autor:
Shang-Te Danny Hsu, Yun-Tzai Cloud Lee, Kornelia M. Mikula, Sofia M. Backlund, Igor Tascón, Adrian Goldman, Hideo Iwaï
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Knots have attracted scientists in mathematics, physics, biology, and engineering. Long flexible thin strings easily knot and tangle as experienced in our daily life. Similarly, long polymer chains inevitably tend to get trapped into knots. Little is
Externí odkaz:
https://doaj.org/article/9c596a763eb44327a9496062bfed193e
Autor:
Annika Ciragan, Sofia M. Backlund, Kornelia M. Mikula, Hannes M. Beyer, O. H. Samuli Ollila, Hideo Iwaï
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The growing understanding of partially unfolded proteins increasingly points to their biological relevance in allosteric regulation, complex formation, and protein design. However, the structural characterization of disordered proteins remains challe
Externí odkaz:
https://doaj.org/article/fa9f4e0518ee43869f0fef3e5dc56c64
Autor:
Hannes M. Beyer, Salla I. Virtanen, A. Sesilja Aranko, Kornelia M. Mikula, George T. Lountos, Alexander Wlodawer, O. H. Samuli Ollila, Hideo Iwaï
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8367 (2020)
Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the prote
Externí odkaz:
https://doaj.org/article/8e51ad775d27471584c9fd0e0da0bc18
Autor:
George T. Lountos, Hideo Iwaï, Hannes M. Beyer, Kornelia M. Mikula, O. H. Samuli Ollila, Alexander Wlodawer, Salla I. Virtanen, A. Sesilja Aranko
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8367, p 8367 (2020)
'International Journal of Molecular Sciences ', vol: 21, pages: 8367-1-8367-20 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 21
'International Journal of Molecular Sciences ', vol: 21, pages: 8367-1-8367-20 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 21
Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the prote
Publikováno v:
Physical chemistry chemical physics : PCCP. 22(37)
Importance of disordered protein regions is increasingly recognized in biology, but their characterization remains challenging due to the lack of suitable experimental and theoretical methods. NMR experiments can detect multiple timescale dynamics an
Autor:
George T. Lountos, Hideo Iwaï, Hannes M. Beyer, O. H. S. Ollila, Salla I. Virtanen, A.S. Aranko, Alexander Wlodawer, Kornelia M. Mikula
The widely used molecular evolutionary clock assumes the divergent evolution of proteins. Convergent evolution has been proposed only for small protein elements but not for an entire protein fold. We investigated the structural basis of the protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41fe63841d00cddcccbf95b67dd6b0d
Autor:
Kornelia M. Mikula, Sofia M. Backlund, Hideo Iwaï, Hannes M. Beyer, Annika Ciragan, O. H. Samuli Ollila
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry
Frontiers in Chemistry
The growing understanding of partially unfolded proteins increasingly points to their biological relevance in allosteric regulation, complex formation, and protein design. However, the structural characterization of disordered proteins remains challe
Autor:
Daniel H. Kwak, Xinyu Liu, Cihad Sigindere, Rose-Marie Andsten, David P. Fewer, Muriel Gugger, Jouni Jokela, Hideo Iwaï, Kaarina Sivonen, Harri Koskela, Jari Yli-Kauhaluoma, Matti Wahlsten, Mikael Jumppanen, Antti Mattila, Michele Assante, Kornelia M. Mikula
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 2019, 14 (12), pp.2683-2690. ⟨10.1021/acschembio.9b00620⟩
ACS Chemical Biology, American Chemical Society, 2019, 14 (12), pp.2683-2690. ⟨10.1021/acschembio.9b00620⟩
ACS Chemical Biology, 2019, 14 (12), pp.2683-2690. ⟨10.1021/acschembio.9b00620⟩
ACS Chemical Biology, American Chemical Society, 2019, 14 (12), pp.2683-2690. ⟨10.1021/acschembio.9b00620⟩
International audience; Prenylation is a common step in the biosynthesis of many natural products and plays an important role in increasing their structural diversity and enhancing biological activity. Muscoride A is a linear peptide alkaloid that co
Publikováno v:
Journal of Structural Biology
Graphical abstract
Highlights • UspA1299–452 is a left-handed coiled-coil structure that follows TAA rules. • Structure of UspA1299–452 contains part of the long neck domain and of the stalk. • UspA1-C3d binding does not saturate at C3
Highlights • UspA1299–452 is a left-handed coiled-coil structure that follows TAA rules. • Structure of UspA1299–452 contains part of the long neck domain and of the stalk. • UspA1-C3d binding does not saturate at C3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c4afb445d2ff62bb9a6b7e580c96c0
Publikováno v:
FEBS J
Protein trans-splicing catalyzed by split inteins has increasingly become useful as a protein engineering tool. We solved the 1.0 A-resolution crystal structure of a fused variant from the naturally split gp41-1 intein, previously identified from env