Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kornel Kistamas"'
Autor:
Balázs Horváth, Tamás Hézső, Dénes Kiss, Kornél Kistamás, János Magyar, Péter P. Nánási, Tamás Bányász
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Based on recent findings, an increased late sodium current (INa,late) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is INa,late and how it functions under physiological ci
Externí odkaz:
https://doaj.org/article/c92bf06a934042b3a5b4b6f6ad8eb8a2
Autor:
Kornél Kistamás, Roland Veress, Balázs Horváth, Tamás Bányász, Péter P. Nánási, David A. Eisner
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also
Externí odkaz:
https://doaj.org/article/4bb86de88be544339c54956f29488316
Autor:
Bence Hegyi, István Komáromi, Kornél Kistamás, Ferenc Ruzsnavszky, Krisztina Váczi, Balázs Horváth, János Magyar, Tamás Bányász, Péter P. Nánási, Norbert Szentandrássy
Publikováno v:
Marine Drugs, Vol 11, Iss 6, Pp 2140-2153 (2013)
Tetrodotoxin (TTX) is believed to be one of the most selective inhibitors of voltage-gated fast Na+ channels in excitable tissues. Recently, however, TTX has been shown to block L-type Ca2+ current (ICa) in canine cardiac cells. In the present study,
Externí odkaz:
https://doaj.org/article/86bb78bbd670445c83456fdbb8464fe0
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Autor:
Tamás Hézső, Muhammad Naveed, Csaba Dienes, Dénes Kiss, János Prorok, Tamás Árpádffy-Lovas, Richárd Varga, Erika Fujii, Tanju Mercan, Leila Topal, Kornél Kistamás, Norbert Szentandrássy, János Almássy, Norbert Jost, János Magyar, Tamás Bányász, István Baczkó, András Varró, Péter P. Nánási, László Virág, Balázs Horváth
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Enhancement of the late Na+ current (INaL) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of INaL. In the present study, effects of GS967
Externí odkaz:
https://doaj.org/article/73d50e33846d4bc7818bb17c0e8b0687