Zobrazeno 1 - 10 of 176 pro vyhledávání: '"Koristka, S"'
1
Highly Efficient Targeting of EGFR-Expressing Tumor Cells with UniCAR T Cells via Target Modules Based on Cetuximab®
Autor: Jureczek J, Feldmann A, Bergmann R, Arndt C, Berndt N, Koristka S, Loureiro LR, Mitwasi N, Hoffmann A, Kegler A, Bartsch T, Bachmann M
Publikováno v: OncoTargets and Therapy, Vol Volume 13, Pp 5515-5527 (2020)
Justyna Jureczek,1– 3 Anja Feldmann,3 Ralf Bergmann,3,4 Claudia Arndt,3 Nicole Berndt,3 Stefanie Koristka,3 Liliana Rodrigues Loureiro,3,5 Nicola Mitwasi,3 Anja Hoffmann,3 Alexandra Kegler,1– 3 Tabea Bartsch,3 Michael Bachmann1– 3,5,6 1German C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::7094288a9c9d989d83513271a9e4559f
https://www.dovepress.com/highly-efficient-targeting-of-egfr-expressing-tumor-cells-with-unicar--peer-reviewed-article-OTT
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2
Antigen-specific redirection of off-the-shelf NK-92 cells using the universal CAR platform ‘‘UniCAR’’
Autor: Mitwasi, N., Feldmann, A., Arndt, C., Koristka, S., Loureiro, L. R., Berndt, N., Tonn, T., Bergmann, R., Rössig, C., Wels, W. S., Bachmann, M.
Publikováno v: International Conference on Lymphocyte Engineering, 31.03.-02.04.2022, Munich, Germany
Modifying of immune effector cells with chimeric antigen receptors (CARs) has revealed a promising therapeutic potential for targeting cancer, especially with CAR-modified T cells. However, the use of other immune cells like primary NK cells or NK ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::b5850174093bb2661da15bd0a4e11666
https://www.hzdr.de/publications/Publ-33879-1
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3
Development of a novel target module redirecting UniCAR T cells to Sialyl Tn-expressing tumor cells
Autor: Loureiro, L., Feldmann, A., Bergmann, R., Koristka, S., Berndt, N., Arndt, C., Pietzsch, J., Novo, C., Videira, P., Bachmann, M.
Publikováno v: Blood Cancer Journal, Vol 8, Iss 9, Pp 1-6 (2018)
Blood Cancer Journal 8(2018), 81
The development of antibody-based therapies has been driven by progress in the immune response field culminating in the development of chimeric antigen receptors (CARs) as a promising approach in cancer immunotherapy. Nevertheless, drawbacks associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f9b7b99a5904b4ecd5cf92f7f3b9d2b4
http://link.springer.com/article/10.1038/s41408-018-0113-4
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4
Adaptor CAR platforms - next generation of T cell-based cancer immunotherapy
Autor: Arndt, C., Fasslrinner, F., Loureiro, L. R., Koristka, S., Feldmann, A., Bachmann, M.
Publikováno v: Cancers 12(2020)5, 1302
The success of conventional chimeric antigen receptor (CAR) therapy in the treatment of refractory hematologic malignancies has triggered the development of novel exciting experimental CAR technologies. Among them, adaptor CAR platforms have received
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::caa19494dab8471ee347387bea730dd4
https://www.hzdr.de/publications/Publ-30960-1
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5
UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cells
Autor: Arndt, C., Loureiro, L. R., Feldmann, A., Jureczek, J., Bergmann, R., Máthé, D., Hegedüs, N., Berndt, N., Koristka, S., Metwasi, N., Fasslrinner, F., Lamprecht, C., Kegler, A., Hoffmann, A., Bartsch, T., Köseer, A. S., Egan, G., Schmitz, M., Hořejší, V., Krause, M., Dubrovska, A., Bachmann, M.
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology
OncoImmunology 9(2020)1, 1743036
Induction or selection of radioresistant cancer (stem) cells following standard radiotherapy is presumably one of the major causes for recurrence of metastatic disease. One possibility to prevent tumor relapse is the application of targeted immunothe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::516e17a113eddc554ee8ab13dece7b60
https://doaj.org/article/e9bde3c3ab474cab96ef8a34e0e398cf
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6
An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells
Autor: Jureczek, J., Bergmann, R., Berndt, N., Koristka, S., Kegler, A., Puentes-Cala, E., Soto, J. A., Arndt, C., Bachmann, M., Feldmann, A.
Publikováno v: Repositorio Universidad de Santander
Universidad de Santander
instacron:Universidad de Santander
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports 9(2019)1, 10547
Digital
Recently, we established the controllable modular UniCAR platform technology to advance the efficacy and safety of CAR T cell therapy. The UniCAR system is composed of (i) target modules (TMs) and (ii) UniCAR armed T cells. TMs are bispe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec668750684f80076d64fc6cb440b4bf
https://repositorio.udes.edu.co/handle/001/5614
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7
Anti-CAR engineered T cells for epitope-based elimination of autologous CAR T cells
Autor: Koristka, S., Ziller-Walter, P., Bergmann, R., Arndt, C., Feldmann, A., Kegler, A., Cartellieri, M., Ehninger, A., Ehninger, G., Bornhäuser, M., Bachmann, M.
Publikováno v: Cancer Immunology, Immunotherapy (2019), 1401-1415
Although CAR T cell therapy has demonstrated tremendous clinical efficacy especially in hematological malignancies, severe treatment-associated toxicities still compromise the widespread application of this innovative technology. Therefore, developin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::b40cd2444002c5b4d53ecbd9f48f2a72
https://www.hzdr.de/publications/Publ-27834-1
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8
Gated targeting with a novel switchable CAR platform technology
Autor: Feldmann, A., Hoffmann, A., Kittel-Boselli, E., Bergmann, R., Koristka, S., Arndt, C., Loureiro, L., Berndt, N., Bachmann, M.
Publikováno v: International Conference on Lymphocyte Engineering (ICLE) 2019, 13.-15.09.2019, London, England
Human Gene Therapy 30(2019)12
T-cells armed with conventional CARs (cCARs) are highly effective especially in hematological malignancies. However, they often fail against solid tumors, induce tumor escape variants and cause life-threatening side effects. The safety of cCAR therap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1c50368c89e4168e6e6b3d420dc66d92
https://www.hzdr.de/publications/Publ-29298-1
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9
T Cell Based Immunotherapy of Acute Myeloid Leukemia is Abrogated by the Tyrosine Kinase Inhibitor Midostaurin
Autor: Fasslrinner, F., Arndt, C., Koristka, S., Feldmann, A., Altmann, H., Bonin, M., Schmitz, M., Bornhäuser, M., Bachmann, M.
Publikováno v: 1st European CAR T Cell Meeting, 14.-16.02.2019, Paris, France
Background Induction chemotherapy is currently the standard of care for treatment of acute myeloid leukemia (AML) with 5-year disease-free survival of 33%. Given the large proportion of non-responders and relapsed patients, novel adjuvant drugs are u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::9f5e0912e4bbc6e459a2f2a19821b97e
https://www.hzdr.de/publications/Publ-29139-1
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10
Development of Novel Anti-CD10 Target Modules for Redirection of Universal CAR T Cells Against CD10-Positive Malignancies
Autor: Feldmann, A., Koristka, S., Arndt, C., Loureiro, L. R., Bergmann, R., Berndt, N., Hoffmann, A., Jureczek, J., Mitwasi, N., Bornhaeuser, M., Hořejší, V., Bachmann, M.
Publikováno v: BLOOD 134(2019), 5612-5612
The common acute lymphoblastic leukemia antigen CD10 is a marker for several hematological malignancies, including acute lymphoblastic leukemia as well as T and B cell lymphomas, Burkitt lymphomas, and some solid tumors like renal cell carcinomas, pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::6d8f581ecc855f139481be4e3a07e106
https://www.hzdr.de/publications/Publ-30161-1
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