Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

Autor: Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Jünger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schröder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth

Publikováno v: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-25 (2022)

Abstract Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5+ mese

Externí odkaz: https://doaj.org/article/4819e8d8b5ba4b6b811f719469da6383

Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data

Autor: Karin Scharffetter-Kochanek, Christoph Ganss, Matthias Goebeler, Natasha Y. Frank, Korinna Kraft, Dennis P. Orgill, Kathrin Dieter, Katrin Rak, Markus H. Frank, Petra Hagenbusch, Samar Sadeghi, Philipp Schrüfer, George F. Murphy, Ana Maria Waaga-Gasser, Andreas Kerstan, Jasmina Esterlechner, Sabrina Endres, Elke Niebergall-Roth, Mark A. Kluth, Seda Ballikaya, Nicole Stemler, Martin Gasser, Nils Tappenbeck, Hannes M. Schröder

Publikováno v: Cytotherapy

Background aim Mesenchymal stromal cells (MSCs) hold promise for the treatment of tissue damage and injury. However, MSCs comprise multiple subpopulations with diverse properties, which could explain inconsistent therapeutic outcomes seen among thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981a1e4206d0daf383a9ccf201bb6cf4
https://doi.org/10.1016/j.jcyt.2020.08.012

Allogeneic ABCB5

Autor: Andreas, Kerstan, Kathrin, Dieter, Elke, Niebergall-Roth, Ann-Kathrin, Dachtler, Korinna, Kraft, Markus, Stücker, Georg, Daeschlein, Michael, Jünger, Tobias, Görge, Ulrich, Meyer-Pannwitt, Cornelia, Erfurt-Berge, Charlotte, von Engelhardt, Andreas, Klare, Christiane, Pfeiffer, Jasmina, Esterlechner, Hannes M, Schröder, Martin, Gasser, Ana M, Waaga-Gasser, Matthias, Goebeler, Seda, Ballikaya, Samar, Sadeghi, George F, Murphy, Dennis P, Orgill, Natasha Y, Frank, Christoph, Ganss, Karin, Scharffetter-Kochanek, Markus H, Frank, Mark A, Kluth

Publikováno v: JID Innov

A significant number of chronic venous ulcers (CVUs) fail to heal despite of guideline-conform standard of care. Skin-derived ABCB5(+) mesenchymal stem cells (MSCs) can dampen the sustained IL-1β-driven inflammation present in chronic wounds. Based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f0ab9a4f78793d799d989e904ffacbe
https://pubmed.ncbi.nlm.nih.gov/34870260

The Bacillus BioBrick Box: generation and evaluation of essential genetic building blocks for standardized work with Bacillus subtilis

Autor: Jara, Radeck, Korinna, Kraft, Julia, Bartels, Tamara, Cikovic, Franziska, Dürr, Jennifer, Emenegger, Simon, Kelterborn, Christopher, Sauer, Georg, Fritz, Susanne, Gebhard, Thorsten, Mascher

Publikováno v: Journal of Biological Engineering

Background Standardized and well-characterized genetic building blocks are a prerequisite for the convenient and reproducible assembly of novel genetic modules and devices. While numerous standardized parts exist for Escherichia coli, such tools are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49b3e38c82e34980e2d4ff6dc18c4c5d
https://pubmed.ncbi.nlm.nih.gov/24295448

Translational development of ABCB5⁺ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers.

Autor: Kerstan, Andreas¹ (AUTHOR), Dieter, Kathrin² (AUTHOR), Niebergall-Roth, Elke³ (AUTHOR), Klingele, Sabrina³ (AUTHOR), Jünger, Michael⁴ (AUTHOR), Hasslacher, Christoph⁵ (AUTHOR), Daeschlein, Georg^4,6 (AUTHOR), Stemler, Lutz⁷ (AUTHOR), Meyer-Pannwitt, Ulrich⁸ (AUTHOR), Schubert, Kristin⁹ (AUTHOR), Klausmann, Gerhard¹⁰ (AUTHOR), Raab, Titus¹¹ (AUTHOR), Goebeler, Matthias¹ (AUTHOR), Kraft, Korinna² (AUTHOR), Esterlechner, Jasmina³ (AUTHOR), Schröder, Hannes M.² (AUTHOR), Sadeghi, Samar³ (AUTHOR), Ballikaya, Seda³ (AUTHOR), Gasser, Martin¹² (AUTHOR), Waaga-Gasser, Ana M.^12,13 (AUTHOR)

Publikováno v: Stem Cell Research & Therapy. 9/5/2022, Vol. 13 Issue 1, p1-25. 25p.