Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Koren K Mann"'
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background E-cigarette use is now prevalent among adolescents and young adults, raising concerns over potential adverse long-term health effects. Although it is hypothesised that e-cigarettes promote inflammation, studies have yielded conflicting evi
Externí odkaz:
https://doaj.org/article/0cade22a136b4277aaab6b4c36ec359f
Autor:
Maryse Lemaire, Luis Fernando Negro Silva, Catherine A Lemarié, Alicia M Bolt, Manuel Flores Molina, Regina M Krohn, Judit E Smits, Stéphanie Lehoux, Koren K Mann
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136592 (2015)
Epidemiological studies have shown that arsenic exposure increases atherosclerosis, but the mechanisms underlying this relationship are unknown. Monocytes, macrophages and platelets play an important role in the initiation of atherosclerosis. Circula
Externí odkaz:
https://doaj.org/article/c951090ee075480898d0d939fefd54c7
Autor:
Cynthia Guilbert, Matthew G Annis, Zhifeng Dong, Peter M Siegel, Wilson H Miller, Koren K Mann
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85995 (2013)
Inhibitors of the mammalian target of rapamycin (mTORi) have clinical activity; however, the benefits of mTOR inhibition by rapamycin and rapamycin-derivatives (rapalogs) may be limited by a feedback mechanism that results in AKT activation. Increase
Externí odkaz:
https://doaj.org/article/e2adce2e6ec64ade8b56e89c14c6e431
Autor:
Alexandre Benoit, Elisabeth Bou-Petit, Hsiang Chou, Melissa Lu, Cynthia Guilbert, Vincent Mingyi Luo, Sarit Assouline, Ryan D. Morin, Svetlana Dmitrienko, Roger Estrada-Tejedor, Nathalie A. Johnson, Koren K. Mann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Diffuse large B cell lymphoma (DLBCL) is successfully treated with combination immuno-chemotherapy, but relapse with resistant disease occurs in ~ 40% of patients. However, little is known regarding relapsed/refractory DLBCL (rrDLBCL) geneti
Externí odkaz:
https://doaj.org/article/4fffe71040f44cc9b5dac6235bfe475e
Autor:
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting i
Externí odkaz:
https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
Autor:
Kiran Makhani, Chris Chiavatti, Luis Fernando Negro Silva, Maryse Lemaire, Alicia M Bolt, Nicolas De Jay, Braeden Giles, Ayse Nazli Zengin, Claudia L Kleinman, Koren K Mann
Publikováno v:
Toxicological Sciences. 192:83-96
Arsenic exposure is correlated with atherosclerosis in epidemiological studies and in animal models. We have previously shown that arsenic exposure enhanced the atherosclerotic plaque size, increased the plaque lipid content, and decreased the plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0342060bfb7d797df828dc4f1bd6a5cd
https://doi.org/10.1093/toxsci/kfad001
https://doi.org/10.1093/toxsci/kfad001
Autor:
Ryuhjin Ahn, Valérie Sabourin, Alicia M. Bolt, Steven Hébert, Stephanie Totten, Nicolas De Jay, Maria Carolina Festa, Yoon Kow Young, Young Kyuen Im, Tony Pawson, Antonis E. Koromilas, William J. Muller, Koren K. Mann, Claudia L. Kleinman, Josie Ursini-Siegel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Tyrosine kinase signalling in cancer cells promotes immune evasion. Here, the authors show that tyrosine kinases engage scaffold protein Shc1 to promote immunosuppression in breast cancer by simultaneously activating STAT3 immunosuppressive signals a
Externí odkaz:
https://doaj.org/article/4564af3090224e7180bdbbc6e315baaa
Autor:
Wilson H. Miller, Jonathan D. Licht, Sonia V. del Rincón, Koren K. Mann, Nathalie A. Johnson, Ryan N. Rys, Mena Kinal, Alberto Riva, Madelyn Jean Abraham, Daphné Dupéré-Richer, Filippa Pettersson, Audrey Emond, Samuel E.J. Preston
Supplementary Figure from Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caefb32468887e6d8bae1e8364abe19
https://doi.org/10.1158/1535-7163.22522573
https://doi.org/10.1158/1535-7163.22522573
Autor:
Wilson H. Miller, Jonathan D. Licht, Sonia V. del Rincón, Koren K. Mann, Nathalie A. Johnson, Ryan N. Rys, Mena Kinal, Alberto Riva, Madelyn Jean Abraham, Daphné Dupéré-Richer, Filippa Pettersson, Audrey Emond, Samuel E.J. Preston
Supplementary Data from Acquired Resistance to EZH2 Inhibitor GSK343 Promotes the Differentiation of Human DLBCL Cell Lines toward an ABC-Like Phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0ff956dfbacbd752d5b21c5356b429
https://doi.org/10.1158/1535-7163.22522579.v1
https://doi.org/10.1158/1535-7163.22522579.v1
Autor:
Wilson H. Miller, Jonathan D. Licht, Sonia V. del Rincón, Koren K. Mann, Nathalie A. Johnson, Ryan N. Rys, Mena Kinal, Alberto Riva, Madelyn Jean Abraham, Daphné Dupéré-Richer, Filippa Pettersson, Audrey Emond, Samuel E.J. Preston
Diffuse large B-cell lymphoma (DLBCL) accounts for 40% of non-Hodgkin lymphoma, and 30% to 40% of patients will succumb to relapsed/refractory disease (rrDLBCL). Patients with rrDLBCL generally have low long-term survival rates due to a lack of effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e31b9732a90a20cb2c987e58616837
https://doi.org/10.1158/1535-7163.c.6543439
https://doi.org/10.1158/1535-7163.c.6543439