Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Koren K, Mann"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-34 (2024)
Abstract Single-cell multi-omics data reveal complex cellular states, providing significant insights into cellular dynamics and disease. Yet, integration of multi-omics data presents challenges. Some modalities have not reached the robustness or clar
Externí odkaz:
https://doaj.org/article/2f7dbb898cec4e45933079a8ea301663
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background E-cigarette use is now prevalent among adolescents and young adults, raising concerns over potential adverse long-term health effects. Although it is hypothesised that e-cigarettes promote inflammation, studies have yielded conflicting evi
Externí odkaz:
https://doaj.org/article/0cade22a136b4277aaab6b4c36ec359f
Autor:
Madelyn J. Abraham, Christophe Goncalves, Paige McCallum, Vrinda Gupta, Samuel E. J. Preston, Fan Huang, Hsiang Chou, Natascha Gagnon, Nathalie A. Johnson, Wilson H. Miller, Koren K. Mann, Sonia V. del Rincon
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract Background The tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex single cell spatial biology imaging platform, is used to characterize the complexity of the
Externí odkaz:
https://doaj.org/article/6fa7d5ed303140b2a9d3879799bd4241
Autor:
Talin Ebrahimian, France Dierick, Vincent Ta, Maria Kotsiopriftis, Jonathan O’Connor Miranda, Koren K. Mann, Alexandre Orthwein, Stephanie Lehoux
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Antigen-naive IgM-producing B cells are atheroprotective, whereas mature B cells producing class-switched antibodies promote atherosclerosis. Activation-induced cytidine deaminase (AID), which mediates class switch recombination (CSR), would
Externí odkaz:
https://doaj.org/article/46c5d8ed292f491ba4c713375be2a4b3
Autor:
Bayan Alakhtar, Cynthia Guilbert, Nivetha Subramaniam, Vincenza Caruana, Kiran Makhani, Carolyn J. Baglole, Koren K. Mann
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Introduction: Evidence suggests that e-cigarette use (vaping) increases cardiovascular disease risk, but decades are needed before people who vape would develop pathology. Thus, murine models of atherosclerosis can be utilized as tools to understand
Externí odkaz:
https://doaj.org/article/342f357089b74edf812ca2357197e51b
Autor:
Gervasio A. Lamas, Aruni Bhatnagar, Miranda R. Jones, Koren K. Mann, Khurram Nasir, Maria Tellez‐Plaza, Francisco Ujueta, Ana Navas‐Acien
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 13 (2023)
Exposure to environmental pollutants is linked to increased risk of cardiovascular disease. Beyond the extensive evidence for particulate air pollution, accumulating evidence supports that exposure to nonessential metals such as lead, cadmium, and ar
Externí odkaz:
https://doaj.org/article/90320c39305c481b8487747e6e627263
Autor:
Alexandre Benoit, Elisabeth Bou-Petit, Hsiang Chou, Melissa Lu, Cynthia Guilbert, Vincent Mingyi Luo, Sarit Assouline, Ryan D. Morin, Svetlana Dmitrienko, Roger Estrada-Tejedor, Nathalie A. Johnson, Koren K. Mann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Diffuse large B cell lymphoma (DLBCL) is successfully treated with combination immuno-chemotherapy, but relapse with resistant disease occurs in ~ 40% of patients. However, little is known regarding relapsed/refractory DLBCL (rrDLBCL) geneti
Externí odkaz:
https://doaj.org/article/4fffe71040f44cc9b5dac6235bfe475e
Autor:
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting i
Externí odkaz:
https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
Autor:
Kiran Makhani, Chris Chiavatti, Luis Fernando Negro Silva, Maryse Lemaire, Alicia M Bolt, Nicolas De Jay, Braeden Giles, Ayse Nazli Zengin, Claudia L Kleinman, Koren K Mann
Publikováno v:
Toxicological Sciences. 192:83-96
Arsenic exposure is correlated with atherosclerosis in epidemiological studies and in animal models. We have previously shown that arsenic exposure enhanced the atherosclerotic plaque size, increased the plaque lipid content, and decreased the plaque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0342060bfb7d797df828dc4f1bd6a5cd
https://doi.org/10.1093/toxsci/kfad001
https://doi.org/10.1093/toxsci/kfad001
Autor:
Benet Pera, Jan Krumsiek, Sarit E. Assouline, Rossella Marullo, Jayeshkumar Patel, Jude M. Phillip, Lidia Román, Koren K. Mann, Leandro Cerchietti
Publikováno v:
EBioMedicine, Vol 28, Iss C, Pp 80-89 (2018)
Despite the proven clinical antineoplastic activity of histone deacetylase inhibitors (HDACI), their effect has been reported to be lower than expected in B-cell lymphomas. Traditionally considered as “epigenetic drugs”, HDACI modify the acetylat
Externí odkaz:
https://doaj.org/article/70c266c93da24d23921073b49e235d89